Ahmann 1976b.

Study characteristics
Methods	As for Ahmann 1976a
Participants	As for Ahmann 1976a
Interventions	Ahmann 1976b = CF (with Prednisone) vs CAF
Outcomes	As for Ahmann 1976a
Notes	As for Ahmann 1976a
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	B ‐ Unclear
Allocation concealment (selection bias)	Unclear risk	B ‐ Unclear
Blinding (performance bias and detection bias) All outcomes	Unclear risk	B ‐ Unclear
Incomplete outcome data (attrition bias) Response	Low risk	A ‐ Adequate
Incomplete outcome data (attrition bias) Toxicity	Low risk	A ‐ Adequate
Incomplete outcome data (attrition bias) Time to progression	Low risk	A ‐ Adequate
Selective reporting (reporting bias)	Unclear risk	B ‐ Unclear
Other bias	Unclear risk	B ‐ Unclear