| Study characteristics |
| Methods |
As for Cavalli 1983a |
| Participants |
As for Cavalli 1983a |
| Interventions |
Cavalli 1983b = CLB+MFVP vs CLB+MFP |
| Outcomes |
As for Cavalli 1983a |
| Notes |
As for Cavalli 1983a except doses of the same chemotherapy agent are increased in the addition of a drug arm (cycles remain the same between treatment arms) |
| Risk of bias |
| Bias |
Authors' judgement |
Support for judgement |
| Random sequence generation (selection bias) |
Unclear risk |
B ‐ Unclear |
| Allocation concealment (selection bias) |
Unclear risk |
B ‐ Unclear |
| Blinding (performance bias and detection bias)
All outcomes |
Unclear risk |
B ‐ Unclear |
| Incomplete outcome data (attrition bias)
Response |
Low risk |
A ‐ Adequate |
| Incomplete outcome data (attrition bias)
Toxicity |
Unclear risk |
B ‐ Unclear |
| Incomplete outcome data (attrition bias)
Time to progression |
Low risk |
A ‐ Adequate |
| Incomplete outcome data (attrition bias)
Overall survival |
Low risk |
A ‐ Adequate |
| Selective reporting (reporting bias) |
Low risk |
A ‐ Adequate, outcomes reported |
| Other bias |
Unclear risk |
B ‐ Unclear, mean age of pre‐ and post‐menopausal groups not mentioned in each treatment group |
