| Study characteristics |
| Methods |
As for Nemoto 1982a |
| Participants |
As for Nemoto 1982a |
| Interventions |
Nemoto 1982b = AC vs CAF |
| Outcomes |
As for Nemoto 1982a |
| Notes |
As for Nemoto 1982a except doses of the same chemotherapy agent are reduced in the addition of a drug arm |
| Risk of bias |
| Bias |
Authors' judgement |
Support for judgement |
| Random sequence generation (selection bias) |
Unclear risk |
B ‐ Unclear |
| Allocation concealment (selection bias) |
Low risk |
A ‐ Adequate, closed envelope |
| Blinding (performance bias and detection bias)
All outcomes |
Unclear risk |
B ‐ Unclear |
| Incomplete outcome data (attrition bias)
Response |
Low risk |
A ‐ Adequate |
| Incomplete outcome data (attrition bias)
Toxicity |
Low risk |
A ‐ Adequate |
| Incomplete outcome data (attrition bias)
Time to progression |
Unclear risk |
B ‐ Unclear |
| Incomplete outcome data (attrition bias)
Overall survival |
High risk |
C ‐ Inadequate |
| Selective reporting (reporting bias) |
Unclear risk |
B ‐ Unclear |
| Other bias |
Low risk |
A ‐ Adequate |
