Ahmad 2006.

Methods	Parallel group, randomised
Participants	Children, mean age 19 years, 55% male, setting: tertiary hospital
Interventions	Arm 1: Intranasal Lorazepam 100 microgram/kg Arm 2: IM Paraldehyde 0.2 mL/kg
Outcomes	Cessation of seizures within 10 minutes of administration of drug Deaths in hospital
Notes	Study from Malawi, single centre. Funded by UK college of Emergency Medicine
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	Blocked randomisation by computer‐generated random number table
Allocation concealment (selection bias)	Low risk	Allocations were sealed in unmarked identical envelopes. Investigators were masked to these allocations before the point of patient treatment
Blinding of participants and personnel (performance bias) All outcomes	Unclear risk	Lack of blinding may have affected institution of co‐intervention
Blinding of outcome assessment (detection bias) All outcomes	Low risk	Even though not blinded, outcomes such as seizure activity determination is unlikely to be subject to bias in detection