Price 1998.
Methods | Randomisation: sealed and numbered envelopes. Blinding: mother and outcome assessments. Criteria for rescue: additional analgesia delivered as 10 mL bupivacaine 0.25%. Statistics not performed on intention‐to‐treat basis. |
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Participants | Inclusions: 100 women in labour cervix < 6 cm dilated. Exclusions: pethidine < 3 hr before epidural request, pregnancy‐induced hypertension. No. lost to follow‐up = 7. | |
Interventions | Epidural (n = 48): 15 mL bupivacaine 0.1% + fentanyl 75 µg bolus then PCEA 10 mL bupivacaine 0.1% + fentanyl 2 µg/mL with 30 min lockout. CSE (n = 45): single space, needle‐through‐needle, lateral position, IT LA: 2.5 mg bupivacaine + 25 µg fentanyl then PCEA 15 mL 0.1% bupivacaine + fentanyl 2 µg/mL, 30 min. |
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Outcomes | Pain scores and motor block at 0, 30, 60, 180 min. Maternal confidence in walking. Time to first epidural top‐up and need for additional analgesia. Adverse effects: hypotension (no definition given), pruritus, need for urinary catheterisation. Maternal satisfaction postpartum #1. | |
Notes | UK. | |
Risk of bias | ||
Bias | Authors' judgement | Support for judgement |
Random sequence generation (selection bias) | Unclear risk | Method of randomisation not stated. |
Allocation concealment (selection bias) | Low risk | Used "sealed, numbered envelopes". |
Blinding (performance bias and detection bias) All outcomes | Low risk | The patient and the investigator were blinded. |
Incomplete outcome data (attrition bias) All outcomes | Low risk | There was no loss to follow‐up and drop out was similar in both groups (7 in total). |
Selective reporting (reporting bias) | Low risk | Primary and secondary outcomes are reported. |
Other bias | Low risk | No other bias evident. |