| Sampling age |
5 m |
7 m |
2.6 y |
4.0 y |
4.3 y |
7.5 y |
8.8 y |
9.5 y |
|
|
| tauro-THBA |
227 |
232 |
12 |
1 |
0 |
32 |
0 |
26 |
0.8 (0, 1.4) |
156.5 (14.1, 273.6) |
| glyco-UDCA-3-sulfate |
5,194 |
8,045 |
14,895 |
11,517 |
8,790 |
11,714 |
13,250 |
34,294 |
90 (48.6, 143.1) |
14,391.8 (5,136.6, 83,232.4) |
| tauro-UDCA-3-sulfate |
4,171 |
5,337 |
19 |
13 |
9 |
11,961 |
7 |
19 |
0.3 (0.1, 14.5) |
8,690 (2,070.5, 27,430.1) |
| glyco-CA-3-sulfate |
17 |
4 |
233 |
76 |
19 |
1 |
47 |
223 |
0.8 (0.3, 1.8) |
183.3 (2.2, 319.6) |
| tauro-dehydro-CA |
0.4 |
0.5 |
0 |
0 |
0 |
0.2 |
0 |
0 |
0.2 (0, 0.2) |
0.3 (0.2, 1) |
| tauro-ω-MCA |
68.5 |
0 |
0 |
0 |
0 |
37.4 |
2.6 |
42.7 |
0.2 (0, 2) |
137.9 (22.8, 476.7) |
| tauro-α-MCA |
931 |
506 |
100 |
62 |
54 |
43 |
1 |
47 |
6.3 (0.5, 20.1) |
730.6 (84.5, 1,711) |
| tauro-β-MCA |
1,096 |
590 |
191 |
32 |
39 |
6 |
20 |
283 |
1.5 (0.2, 2.4) |
396.8 (50, 1,865.3) |
| glyco-dehydro-CA |
0.1 |
0 |
0 |
6.3 |
1.7 |
0 |
0 |
0 |
0 (0, 1.2) |
0 (0, 2) |
| THBA |
0.4 |
0.4 |
6.3 |
3.5 |
4.4 |
0.2 |
0 |
0.1 |
0.4 (0.3, 2.5) |
1.8 (0.3, 33.5) |
| glyco-DCA-3-sulfate |
0 |
0 |
2.3 |
0 |
0 |
0 |
1,293 |
1,417.9 |
50.1 (4.3, 85.8) |
0.8 (0, 1.8) |
| tauro-CDCA-3-sulfate |
27,854 |
16,699 |
16 |
16 |
8 |
5,292 |
0 |
0 |
0.7 (0.1, 90.3) |
10,196 (4,111.4, 29,233.7) |
| tauro-HCA |
3,837 |
2,852 |
419 |
330 |
172 |
198 |
48 |
648 |
8.6 (0, 21.6) |
1,713.5 (1,273.9, 2,818) |
| CA-3-sulfate |
54.9 |
110.5 |
20.8 |
10.9 |
3.4 |
6.9 |
7.4 |
24.7 |
0.8 (0.3, 1.8) |
27.5 (18.7, 41.4) |
| tauro-DCA-3-sulfate |
0 |
0 |
0 |
0.4 |
0 |
252.6 |
1 |
2.7 |
0.1 (0, 3.4) |
0.2 (0, 3.3) |
| tauro-HDCA |
19387 |
4286.2 |
1.7 |
0.3 |
0.2 |
61,032 |
4.7 |
4.2 |
0 (0, 14.1) |
8,690 (2,070.5, 27,430.1) |
| tauro-UDCA |
20,149 |
4,739 |
14,691 |
13,979 |
39,234 |
61,662 |
1,271 |
11,856 |
16.2 (4.8, 26.6) |
10,812.1 (1,719.8, 32,152.5) |
| glyco-LCA-3-sulfate |
120.7 |
0 |
24.9 |
40.4 |
28.1 |
123.7 |
1,398.6 |
1,762.5 |
50 (7.7, 140.7) |
54.2 (39.1, 68.7) |
| UCA |
2.1 |
2.3 |
7.8 |
5.3 |
1.9 |
2.2 |
0 |
0 |
2.6 (1.3, 4.7) |
4.1 (2.1, 16.8) |
| 7,12-keto-LCA |
379.2 |
576.7 |
2.8 |
0.1 |
2.3 |
594.8 |
0 |
0 |
3.4 (0, 9.9) |
28.4 (2, 151.4) |
| glyco-HCA |
1,322 |
1,647 |
406 |
400 |
167 |
141 |
348 |
1,276 |
42.9 (30.3, 96.8) |
1,156.3 (338.2, 1,515.1) |
| tauro-LCA-3-sulfate |
91.4 |
12.4 |
0.2 |
0.1 |
0.1 |
0.7 |
1.4 |
0 |
0.1 (0, 0.7) |
20.5 (4.1, 88.1) |
| dehydro-CA |
5 |
3.5 |
1.4 |
1.8 |
0 |
2 |
3.7 |
14.7 |
10.2 (6.7, 18.6) |
2.3 (0.6, 10.3) |
| ω-MCA |
0.3 |
0.3 |
3.5 |
9.9 |
18.2 |
0.5 |
8 |
22.2 |
2.9 (0.3, 15.9) |
2.8 (1.5, 3.9) |
| glyco-UDCA |
30,655 |
25,544 |
56,811 |
70,169 |
141,921 |
156,371 |
17,697 |
123,036 |
293.5 (87.8, 531.2) |
53,559.2 (25,854.3, 99,666.6) |
| glyco-HDCA |
0 |
0 |
19.1 |
28.5 |
27 |
0 |
19.3 |
0 |
2 (0, 4.5) |
16.2 (0, 18,612.7) |
| α-MCA |
0.5 |
0.7 |
30.8 |
29.1 |
1.8 |
0.9 |
1.9 |
4.1 |
4.9 (0.4, 15.1) |
6.6 (2.9, 7.5) |
| nor-CA |
32 |
28.2 |
50.6 |
60.3 |
27.4 |
28.8 |
29.5 |
38.5 |
21.9 (12.9, 33.7) |
36 (14.7, 46.9) |
| nor-UDCA |
30.4 |
3.5 |
2.6 |
4.7 |
1.5 |
14.4 |
63.4 |
17.9 |
4.4 (2.3, 10.5) |
29.9 (19.2, 31.3) |
| 7-keto-DCA |
1.3 |
1.9 |
0.3 |
8.5 |
7.5 |
1.7 |
8.9 |
5.2 |
2.3 (1.2, 4.1) |
0.9 (0.1, 4.8) |
| DCA-3-sulfate |
0 |
1.2 |
0.1 |
0.1 |
0.1 |
0.6 |
12 |
26.1 |
0.7 (0.3, 1.4) |
0.2 (0.1, 0.5) |
| β-MCA |
0.3 |
2 |
0.5 |
0 |
0.4 |
0.4 |
3.5 |
0.9 |
1 (0.3, 4.1) |
2.8 (1, 11) |
| 12-keto-CDCA |
877 |
1114 |
0 |
78 |
3 |
920 |
0 |
2 |
2.9 (0, 24.3) |
154.9 (12.2, 644.9) |
| HCA |
5.1 |
7.5 |
0 |
0 |
0 |
0.7 |
28.5 |
14.2 |
12.3 (8, 28) |
4.3 (1.6, 19.3) |
| MCA |
1 |
0.4 |
0 |
0 |
0 |
0.4 |
0 |
0 |
0.5 (0, 1.8) |
0.5 (0.2, 2.4) |
| 3-keto-CA |
3.3 |
1.7 |
0.2 |
0 |
1.3 |
0.5 |
3.3 |
3.9 |
0.2 (0, 1) |
1.7 (0.9, 4.4) |
| alloCA |
1.1 |
0.9 |
0.6 |
0.8 |
0 |
0 |
5.9 |
6.5 |
10.9 (5.3, 45.1) |
2.1 (1.3, 8.4) |
| UDCA |
148 |
39 |
119 |
116 |
818 |
411 |
575 |
3,522 |
58.6 (22.7, 148.6) |
1,064.1 (320.2, 6,419.4) |
| HDCA |
1.5 |
0.2 |
0 |
0 |
0 |
1.2 |
0 |
0 |
0 (0, 1.1) |
2.5 (0, 4.5) |
| 7-keto-LCA |
1 |
1.3 |
4 |
6 |
23.8 |
4.3 |
20.8 |
3.1 |
5.7 (0.9, 11.9) |
5.7 (4, 8.3) |
| 6,7-keto-LCA |
0 |
0 |
1 |
12.4 |
16.8 |
0.8 |
6.8 |
9.3 |
0.5 (0.2, 3.6) |
0.2 (0.1, 9.3) |
| nor-DCA |
1.5 |
7.6 |
0 |
0 |
0.4 |
0 |
0 |
0 |
0.4 (0, 1.3) |
2.2 (1.1, 5.9) |
| 12-keto-LCA |
0.3 |
0.2 |
3.2 |
0.8 |
1.9 |
0.1 |
32.1 |
4.1 |
0.2 (0, 4.1) |
0.2 (0.1, 1.5) |
| apoCA |
0.6 |
0.2 |
0 |
0 |
0 |
0.1 |
9.5 |
0 |
0 (0, 0.5) |
0 (0, 0.1) |
| alloisoLCA |
0.5 |
0.6 |
2.1 |
2.3 |
2.7 |
0.8 |
0.3 |
0.2 |
0.9 (0.6, 1.6) |
0.8 (0.3, 3.9) |
| isoLCA |
0.8 |
1 |
0 |
0 |
0 |
1 |
7.1 |
0 |
0 (0, 1.8) |
0.2 (0, 1.1) |
| isoDCA |
0.2 |
0.2 |
0 |
0 |
0 |
0.1 |
1.8 |
0 |
0 (0, 0.1) |
0.3 (0.1, 3.3) |
| dehydro-LCA |
1.8 |
0.9 |
0 |
0 |
0 |
2.3 |
0 |
0 |
0.2 (0, 1.1) |
0.1 (0, 1.2) |
| TBA |
343,407 |
306,040 |
320,255 |
426,327 |
516,707 |
470,453 |
85,289 |
302,824 |
6,128.4 (3,250, 8,364) |
335,544 (216,087, 612,401) |
