Table 2. Comparison of the incidence densities of head and neck cancer in patients with and without chronic pancreatitis according to their demographic characteristics and comorbidities.
| Variables | Chronic pancreatitis | Compared to control | ||||||
|---|---|---|---|---|---|---|---|---|
| Yes | No | |||||||
| Events | PY | Rate# | Events | PY | Rate# | Crude HR (95% CI) | Adjusted HR† (95% CI) | |
| All | 213 | 54,670 | 39.0 | 180 | 61,043 | 29.5 | 1.32 (1.09, 1.62)** | 1.31 (1.07, 1.60)** |
| Sex | ||||||||
| Female | 9 | 9,115 | 9.87 | 3 | 10,438 | 2.87 | 3.44 (0.93, 12.7) | 3.69 (0.98, 13.9) |
| Male | 204 | 45,555 | 44.8 | 177 | 50,604 | 35.0 | 1.28 (1.05, 1.57)* | 1.27 (1.04, 1.56)* |
| Age, years | ||||||||
| 20–49 | 154 | 36,854 | 41.8 | 138 | 39,363 | 35.1 | 1.19 (0.95, 1.50) | 1.20 (0.95, 1.51) |
| 50–64 | 54 | 10,175 | 51.1 | 32 | 12,209 | 26.2 | 1.94 (1.25, 3.01)** | 1.94 (1.24, 3.01)** |
| ≥65 | 7 | 7,641 | 9.16 | 10 | 9,471 | 10.6 | 0.87 (0.33, 2.28) | 0.88 (0.34, 2.33) |
| Occupation | ||||||||
| White collar | 30 | 8,178 | 36.7 | 11 | 9,161 | 12.0 | 3.06 (1.53, 6.10)** | 3.12 (1.56, 6.25)** |
| Blue collar | 79 | 20,547 | 38.5 | 87 | 21,763 | 40.0 | 0.96 (0.71, 1.31) | 0.96 (0.71, 1.30) |
| Others‡ | 104 | 25,945 | 40.1 | 82 | 30,119 | 27.2 | 1.48 (1.11, 1.98)** | 1.46 (1.09, 1.95)* |
| Urbanization level† | ||||||||
| 1 (highest) | 53 | 10,663 | 49.7 | 27 | 12,231 | 22.1 | 2.24 (1.41, 3.57)*** | 2.23 (1.40, 3.54)*** |
| 2 | 64 | 17,110 | 37.4 | 66 | 18,941 | 34.9 | 1.08 (0.76, 1.52) | 1.06 (0.75, 1.50) |
| 3 | 33 | 9,395 | 35.1 | 32 | 10,485 | 30.5 | 1.15 (0.71, 1.87) | 1.15 (0.71, 1.87) |
| 4 (lowest) | 63 | 17,503 | 36.0 | 55 | 19,385 | 28.4 | 1.27 (0.89, 1.83) | 1.27 (0.88, 1.82) |
| Monthly income (NTDs) | ||||||||
| <15,000 | 104 | 25,932 | 40.1 | 82 | 30,129 | 27.2 | 1.48 (1.11, 1.98)** | 1.46 (1.09, 1.95)* |
| 15,000–19,999 | 20 | 3,435 | 58.2 | 16 | 3,834 | 41.7 | 1.39 (0.72, 2.68) | 1.48 (0.76, 2.86) |
| ≥20,000 | 89 | 25,303 | 35.2 | 82 | 27,079 | 30.3 | 1.16 (0.86, 1.57) | 1.16 (0.86, 1.57) |
| Comorbidity§ | ||||||||
| No | 28 | 13,088 | 21.4 | 16 | 15,213 | 10.5 | 2.02 (1.09, 3.73)* | 2.04 (1.10, 3.77)* |
| Yes | 185 | 41,582 | 44.5 | 164 | 45,829 | 35.8 | 1.25 (1.01, 1.54)* | 1.24 (1.01, 1.53)* |
PY, person-years; rate#, incidence rate, per 10,000 person-years; crude HR*: relative hazard ratio. Adjusted HR†: adjusted hazard ratio controlling for age, sex, medical visits frequency, occupation, urbanization level, monthly income, and comorbidity of hyperlipidemia, hypertension, COPD, diabetes, CAD, alcohol-related illness, stroke, asthma, and acute pancreatitis. Comorbidity§: patients with any one of the following comorbidities were classified as the comorbidity group: hyperlipidemia, hypertension, COPD, diabetes, CAD, alcohol-related illness, stroke, asthma, and acute pancreatitis. *, P<0.05; **, P<0.01; ***, P<0.001; †, Urbanization was categorized into four levels according to the population density of the residential area, with level 1 as the most urbanized and level 4 as the least urbanized; ‡, other occupations included primarily retired, unemployed, or low-income populations.