Table 3. Joint effects for head and neck cancer between chronic pancreatitis and head and neck cancer-associated risk factors.
| Variable | N | No. of events | Rate# | Adjusted HR† | 95% CI |
|---|---|---|---|---|---|
| None | 2,420 | 16 | 1.05 | 1 | (Reference) |
| Only chronic pancreatitis | 8,622 | 145 | 3.29 | 2.79 | (1.66, 4.67)*** |
| Only hyperlipidemia | 147 | 1 | 1.03 | 0.90 | (0.12, 6.79) |
| Only hypertension | 9,229 | 186 | 4.26 | 3.53 | (2.12, 5.89)*** |
| Only COPD | 76 | 0 | 0.00 | – | – |
| Only diabetes | 644 | 6 | 1.56 | 1.36 | (0.53, 3.49) |
| Only CAD | 73 | 2 | 4.33 | 5.50 | (1.26, 24.0)* |
| Only alcohol-related illness | 1,180 | 37 | 5.59 | 4.27 | (2.37, 7.70)*** |
| Only stroke | 44 | 0 | 0.00 | – | – |
| Only asthma | 29 | 0 | 0.00 | – | – |
| Only acute pancreatitis | 10 | 0 | 0.00 | – | – |
| Chronic pancreatitis with any one comorbidity | 2,580 | 63 | 4.90 | 4.32 | (2.49, 7.49)*** |
| Chronic pancreatitis with any two comorbidities | 2,378 | 43 | 3.84 | 3.33 | (1.87, 5.93)*** |
| Chronic pancreatitis with any three comorbidities | 2,116 | 38 | 3.74 | 3.22 | (1.79, 5.79)*** |
| Chronic pancreatitis with any four comorbidities | 1,231 | 28 | 5.17 | 4.44 | (2.39, 8.25)*** |
| Chronic pancreatitis with five or more comorbidities | 528 | 13 | 6.60 | 5.78 | (2.77, 12.1)*** |
Rate#, per 1,000 person-years; Adjusted HR†: multivariable analysis incorporating age, sex, medical visits frequency, occupation, urbanization level, and monthly income. *, P<0.05; ***, P<0.001.