Table 3. Univariate and multivariate analysis of preoperative indexes for recurrence by cox regression model.
| Clinicopathologic parameters | Univariate | Multivariate | |||
|---|---|---|---|---|---|
| HR (95% CI) | P value* | HR (95% CI) | P value* | ||
| Age, y: <60 vs. ≥60 | 0.521 (0.247–1.097) | 0.086 | |||
| Gender: female vs. male | 0.852 (0.302–2.406) | 0.763 | |||
| ctDNA status: negative vs. positive | 6.521 (2.520–16.874) | <0.001 | 4.204 (1.498–11.800) | 0.006 | |
| AFP, ng/mL: <20 vs. ≥20 | 1.680 (0.880–3.205) | 0.116 | |||
| AFP, ng/mL: <400 vs. ≥400 | 2.015 (1.062–3.823) | 0.032 | 1.100 (0.530–2.284) | 0.798 | |
| ALT μ/L; <50 vs. ≥50 | 2.392 (1.203–4.747) | 0.013 | 2.238 (1.103–4.540) | 0.026 | |
| AST μ/L; <40 vs. ≥40 | 1.381 (0.729–2.617) | 0.322 | |||
| HBsAg: negative vs. positive | 0.986 (0.410–2.370) | 0.974 | |||
| INR: <1.2 vs. ≥1.2 | 1.182 (0.414–3.378) | 0.755 | |||
| TB, μmol/L: <17.1 vs. ≥17.1 | 1.094 (0.458–2.613) | 0.839 | |||
| ALB, g/L: <40 vs. ≥40 | 1.664 (0.891–3.107) | 0.110 | |||
| Child-Pugh score: A vs. B | 0.985 (0.467–2.078) | 0.969 | |||
| BCLC stage: 0 + A vs. B + C | 4.028 (2.040–7.955) | <0.001 | 2.266 (1.029–4.987) | 0.042 | |
*, analysis by cox regression, with P<0.05 considered significant. INR = (PTtest/PTnormal)ISI. ctDNA, circulating tumor DNA; ALT, alanine aminotransferase; AST, aspartate transaminase; PT, prothrombin time; TB, total bilirubin; ALB, albumin.