Table 6. Univariate and multivariate analysis of MAF and other tumor features for recurrence by cox regression model.
| Clinicopathologic parameters | Univariate | Multivariate | |||
|---|---|---|---|---|---|
| HR (95% CI) | P value* | HR (95% CI) | P value* | ||
| Age, y: <60 vs. ≥60 | 0.588 (0.237–1.460) | 0.252 | |||
| Gender: female vs. male | 1.992 (0.572–6.943) | 0.279 | |||
| ctDNA MAF: decreased vs. increased | 16.827 (6.383–44.358) | <0.001 | 21.469 (7.497–61.480) | <0.001 | |
| Cirrhosis: no vs. yes | 0.879 (0.334–2.317) | 0.795 | |||
| Tumor size, cm: <5 vs. ≥5 | 2.215 (0.839–5.845) | 0.108 | |||
| Tumor number: single vs. multiple | 1.858 (0.874–3.951) | 0.107 | |||
| MVI: no vs. yes | 5.103 (1.183–22.008) | 0.029 | 6.378 (1.449–28.070) | 0.014 | |
| Tumor encapsulation: no vs. yes | 0.664 (0.319–1.382) | 0.274 | |||
| Edmonson grade: I + II vs. III + IV | 1.344 (0.621–2.909) | 0.453 | |||
*, analysis by cox regression, with P<0.05 considered significant. MAF, mutant allele frequency; ctDNA, circulating tumor DNA; MVI, microvascular invasion.