Table 4. The univariate and multivariate with poor overall survival of patients in the SR group.
| Variable | N (%) | Univariate analysis | Multivariate analysis | |||
|---|---|---|---|---|---|---|
| HR (95% CI) | P | HR (95% CI) | P | |||
| Age (y/o) >65/≤65 | 33/57 (36.7/63.3) | 0.839 (0.439−1.601) | 0.594 | |||
| Gender F/M | 15/75 (16.7/83.3) | 0.672 (0.623−1.716) | 0.406 | |||
| BMI (kg/m2) ≥24/<24 | 38/38 (50/50) | 1.074 (0.545−2.115) | 0.836 | |||
| AFP (ng/mL) ≥125/<125 | 43/47 (47.8/52.2) | 1.453 (0.786−2.689) | 0.233 | |||
| Size (cm) >12.5/≤12.5 | 43/47 (47.8/52.2) | 1.107 (0.598−2.049) | 0.746 | |||
| Macrovascular invasion Y/N | 9/81 (10/90) | 1.801 (0.752−4.310) | 0.187 | |||
| Microvascular invasion Y/N | 79/11 (87.8/12.2) | 9.345 (1.280−66.667) | 0.028 | |||
| R0 resection N/Y | 15/75 (16.7/83.3) | 5.649 (2.720−11.732) | <0.001 | 6.341 (2.903−13.851) | <0.001 | |
| HBsAg N/Y | 32/56 (36.4/63.6) | 0.475 (0.232−0.975) | 0.032 | |||
| Anti-HCV N/Y | 72/6 (92.3/7.7) | 1.784 (0.426−7.468) | 0.428 | |||
| ALBI 2 & 3/1 | 54/36 (60/40) | 3.063 (1.506−6.240) | 0.002 | 4.252 (1.998−9.049) | <0.001 | |
| MELD >8/≤8 | 43/47 (44.2/63.8) | 2.176 (1.156−4.096) | 0.016 | |||
| Albumin (mg/dL) ≤3.5/>3.5 | 34/56 (37.8/62.2) | 1.406 (0.377−1.339) | 0.290 | |||
| Platelet (/mm3) >200,000/≤200,000 | 33/57 (36.7/63.3) | 1.060 (0.561−2.004) | 0.856 | |||
| PT INR ≥1.15/<1.15 | 20/70 (28.6/71.4) | 2.115 (1.074−4.165) | 0.030 | |||
| Bilirubin (mg/dL) ≥1.0/<1.0 | 62/28 (68.9/31.1) | 1.647 (0.877−3.092) | 0.121 | |||
| Hgb (mg/dL) ≤12/>12 | 35/55 (38.9/61.1) | 1.006 (0.536−1.889) | 0.985 | |||
| BUN (mg/dL) ≥20/<20 | 21/69 (23.3/76.7) | 0.595 (0.263−1.345) | 0.212 | |||
| Creatinine (mg/dL) ≥1.0/<1.0 | 31/59 (34.4/65.6) | 1.075 (0.567−2.038) | 0.825 | |||
| ALT (U/L) ≥40/<40 | 45/45 (50/50) | 1.047 (0.565−1.941) | 0.885 | |||
| ALKP (U/L) ≥100/<100 | 44/35 (55.7/44.3) | 1.118 (0.582−2.147) | 0.738 | |||
CI, confidence interval; SR, surgical resection; BMI, body mass index; AFP, α-fetoprotein; HBsAg, hepatitis B surface antigen; HCV, hepatitis C virus; MELD, model for end-stage liver disease; ALBI, albumin-bilirubin; PT INR, prothrombin time/international normalized ratio; HgB, hemoglobulin; ALT, alanine aminotransferase; ALKP, alkaline phosphatase.