Table 5. The univariate and multivariate with poor recurrence-free survival of patients in the SR group.
| Variable | N (%) | Univariate analysis | Multivariate analysis | |||
|---|---|---|---|---|---|---|
| HR (95% CI) | P | HR (95% CI) | P | |||
| Age (y/o) >65/≤65 | 33/57 (36.7/63.3) | 1.686 (0.964−2.949) | 0.067 | 2.004 (1.106−3.636) | 0.022 | |
| Gender F/M | 15/75 (16.7/83.3) | 0.463 (0.199−1.078) | 0.074 | |||
| BMI (kg/m2) ≥24/<24 | 38/38 (50/50) | 1.108 (0.632−1.940) | 0.721 | |||
| AFP (ng/mL) ≥125/<125 | 43/47 (47.8/52.2) | 1.750 (1.041−2.941) | 0.035 | 1.772 (1.024−3.067) | 0.041 | |
| Size (cm) >12.5/≤12.5 | 43/47 (47.8/52.2) | 1.208 (0.721−2.025) | 0.472 | |||
| Macrovascular invasion Y/N | 9/81 (10/90) | 1.789 (0.808−3.953) | 0.151 | |||
| Microvascular invasion Y/N | 79/11 (87.8/12.2) | 3.344 (1.199−9.346) | 0.021 | |||
| R0 resection N/Y | 15/75 (16.7/83.3) | 3.861 (1.977−7.542) | <0.001 | 5.458 (2.644−11.264) | <0.001 | |
| HBsAg N/Y | 32/56 (36.4/63.6) | 0.739 (0.416−1.311) | 0.301 | |||
| Anti-HCV N/Y | 72/6 (92.3/7.7) | 0.982 (0.352−2.741) | 0.973 | |||
| ALBI 2 & 3/1 | 54/36 (60/40) | 3.645 (1.992−6.673) | <0.001 | 5.055 (2.687−9.511) | <0.001 | |
| MELD >8/≤8 | 43/47 (44.2/63.8) | 1.385 (0.826−2.322) | 0.217 | |||
| Albumin (mg/dL) ≤3.5/>3.5 | 34/56 (37.8/62.2) | 1.712 (1.011−2.907) | 0.045 | |||
| Platelet (/mm3) >200,000/≤200,000 | 33/57 (36.7/63.3) | 1.122 (0.651−1.933) | 0.679 | |||
| PT INR ≥1.15/<1.15 | 20/70 (28.6/71.4) | 1.477 (0.795−2.746) | 0.217 | |||
| Bilirubin (mg/dL) ≥1.0/<1.0 | 62/28 (68.9/31.1) | 1.471 (0.858−2.523) | 0.161 | |||
| Hgb (mg/dL) ≤12/>12 | 35/55 (38.9/61.1) | 0.720 (0.415−1.251) | 0.244 | |||
| BUN (mg/dL) ≥20/<20 | 21/69 (23.3/76.7) | 0.673 (0.348−1.300) | 0.238 | |||
| Creatinine (mg/dL) ≥1.0/<1.0 | 31/59 (34.4/65.6) | 0.983 (0.570−1.694) | 0.950 | |||
| ALT (U/L) ≥40/<40 | 45/45 (50/50) | 0.991 (0.588−1.699) | 0.972 | |||
| ALKP (U/L) ≥100/<100 | 44/35 (55.7/44.3) | 0.982 (0.558−1.726) | 0.982 | |||
SR, surgical resection; CI, confidence interval; BMI, body mass index; AFP, α-fetoprotein; HBsAg, hepatitis B surface antigen; HCV, hepatitis C virus; MELD, model for end-stage liver disease; ALBI, albumin-bilirubin; PT INR, prothrombin time/international normalized ratio; HgB, hemoglobulin; ALT, alanine aminotransferase; ALKP, alkaline phosphatase.