Table S1. Quantitative summary of the effects of PITX2 overexpression on human atrial electrical activity at the single cell level.
| Model | Quantity | SR (F=0.0) | CAF (F=0.5) | CAF (F=1.0) | CAF (F=1.5) |
|---|---|---|---|---|---|
| Grandi model | Resting potential (mV) | –73.19 | –73.19 | –73.19 | –73.19 |
| APD90 (ms) | 319.94 | 228.40 | 191.98 | 170.47 | |
| Overshoot (ms) | 27.04 | 27.02 | 26.99 | 26.96 | |
| dV/dtmax (mV/ms) | 213.95 | 213.91 | 213.88 | 213.85 | |
| Skibsbye model | Resting potential (mV) | –74.63 | –74.63 | –74.63 | –74.63 |
| APD90 (ms) | 286.66 | 181.97 | 136.77 | 117.45 | |
| Overshoot (ms) | 37.30 | 37.17 | 37.04 | 36.91 | |
| dV/dtmax (mV/ms) | 220.71 | 220.61 | 220.51 | 220.40 |
PITX2, paired-like homeodomain transcription factor 2; SR, sinus rhythm; CAF, chronic atrial fibrillation; APD90, AP repolarization at 90%.