Table 3. Multivariate Cox regression analysis of OS and CSS in the training cohort.
| Variable | OS | CSS | |||||
|---|---|---|---|---|---|---|---|
| HR | 95% CI | P | HR | 95% CI | P | ||
| Tumor grade | |||||||
| I | 1 | 1 | |||||
| II | 1.373 | 1.122–1.680 | 0.002 | 1.497 | 1.201–1.867 | <0.001 | |
| III/IV | 1.956 | 1.587–2.410 | <0.001 | 2.197 | 1.749–2.760 | <0.001 | |
| T stage | |||||||
| T1 | 1 | 1 | |||||
| T2 | 0.95 | 0.801–1.126 | 0.553 | 0.906 | 0.757–1.083 | 0.277 | |
| T3 | 0.88 | 0.698–1.109 | 0.279 | 0.832 | 0.653–1.061 | 0.138 | |
| T4 | 0.951 | 0.779–1.161 | 0.622 | 0.9 | 0.730–1.109 | 0.323 | |
| Histological type | |||||||
| Ductal | 1 | 1 | |||||
| Lobular | 1.275 | 1.077–1.509 | 0.005 | 1.327 | 1.111–1.586 | 0.002 | |
| Mixed ductal and lobular | 1.115 | 0.887–1.401 | 0.351 | 1.139 | 0.896–1.447 | 0.288 | |
| Others | 1.415 | 1.160–1.726 | 0.001 | 1.438 | 1.171–1.765 | 0.001 | |
| Tumor size (cm) | |||||||
| <5 | 1 | 1 | |||||
| 5–10 | 1.242 | 1.070–1.442 | 0.004 | 1.274 | 1.089–1.490 | 0.002 | |
| >10 | 1.581 | 1.269–1.970 | <0.001 | 2.674 | 1.334–2.100 | <0.001 | |
| Tumor subtype | |||||||
| Luminal A | 1 | 1 | |||||
| Luminal B | 0.831 | 0.714–0.968 | 0.017 | 0.783 | 0.667–0.919 | 0.003 | |
| HER2+ | 0.987 | 0.795–1.226 | 0.907 | 0.94 | 0.750–1.179 | 0.592 | |
| Triple-negative | 3.217 | 2.755–3.757 | <0.001 | 3.196 | 2.720–3.756 | <0.001 | |
| Surgery | |||||||
| Yes | 1 | 1 | |||||
| No | 1.664 | 1.490–1.858 | <0.001 | 1.65 | 1.470–1.852 | <0.001 | |
| Chemotherapy | |||||||
| Yes | 1 | 1 | |||||
| No | 1.595 | 1.426–1.783 | <0.001 | 1.557 | 1.385–1.751 | <0.001 | |
| Number of metastatic organs except bone | |||||||
| 0 | 1 | 1 | |||||
| 1 | 1.585 | 1.414–1.777 | <0.001 | 1.655 | 1.468–1.867 | <0.001 | |
| ≥2 | 2.664 | 2.294–3.093 | <0.001 | 2.843 | 2.430–3.326 | <0.001 | |
Grade I: well differentiated; Grade II: moderately differentiated; Grade III: poorly differentiated; Grade IV: undifferentiated anaplastic. OS, overall survival; CSS, cancer-specific survival.