Table 5. Prognostic factors for lymph node metastasis for ICC patients after Surgery.
| Factor | Univariate analysis | Multivariate analysisb | ||
|---|---|---|---|---|
| P value | OR (95% CI) | P value | ||
| Age ≥60 years | 0.235 | – | – | |
| Female | 0.914 | – | – | |
| BMI ≥24 kg/m2 | 0.169 | – | – | |
| Comorbidity | 0.418 | – | – | |
| ASA score 3–4 | 0.580 | – | – | |
| Cirrhosis | 0.551 | – | – | |
| HBsAg (+) | 0.223 | – | – | |
| Tumor size ≥5 cm | 0.453 | – | – | |
| Multiple metastases | 0.045 | 6.159 (1.304–29.104) | 0.022 | |
| Tumor location | ||||
| Left liver lobe | 0.372 | – | – | |
| Central tumor | 0.624 | – | – | |
| TBIL ≥21 μmol/L | 0.930 | – | – | |
| AST ≥40 U/L | 0.280 | – | – | |
| ALT ≥50 U/L | 0.701 | – | – | |
| GGT ≥60 U/L | 0.376 | – | – | |
| Preoperative CA19-9 ≥997.80 U/mL | <0.001 | 8.720 (2.439–31.174) | 0.001 | |
| Preoperative D-dimer ≥0.575 mg/L | 0.007 | – | – | |
| Preoperative CEA ≥2.53 ng/mL | <0.001 | 3.144 (1.116–8.861) | 0.030 | |
| Preoperative FIB ≥3.67 g/L | 0.016 | – | – | |
| The prognostic value on CPDC scorea | <0.001 | 0.006 | ||
| CPDC =0 | Reference | |||
| CPDC =1 | 2.942 (1.068–8.105) | 0.037 | ||
| CPDC =2 | 13.850 (2.337–82.095) | 0.004 | ||
a, because the CPDC score was based on the D-dimer levels and CA19-9 levels, the multivariate analysis of the predictive value of CPDC score for lymph node metastasis included factors with a P<0.1 in univariate analysis exclude of the D-dimer levels and CA19-9 levels. b, clinicopathological factors with a P<0.1 in univariate analysis were included in multivariate analysis. Multivariable analysis was performed using logistic regression analysis. Forward: LR was used in multivariate analysis. ICC, intrahepatic cholangiocarcinoma; OR, odds ratio; CI, confidence interval; BMI, body mass index; ASA, American Society of Anesthesiologists; HBsAg, serum hepatitis B surface antigen; TBIL, total bilirubin; AST, aspartate aminotransferase; ALT, alanine aminotransferase; GGT, gamma glutamyl transferase; CEA, carcinoembryonic antigen; FIB, fibrinogen; CPDC, combination of preoperative D-dimer and CA19-9; LR, likelihood ratio.