Figure 2.

Gene expression profile and gene ontology analysis. (A) By comparing the differential gene expressions of HFF and BJ cell lines in FAP over-expression groups (FAP-HFF, FAP-BJ) and negative control groups (NC-HFF, NC-BJ), it was found that there were 1,172 genes in the HFF groups and 304 genes in the BJ groups. (B,C) Gene ontology analysis indicated that FAP-α might be involved in multiple biological processes, including angiogenesis, extracellular matrix organization, and mitotic nuclear division. (D,E) Pathway analysis further indicated that pantothenate and CoA biosynthesis, focal adhesion, and another pathways may be activated by FAP-α. BP, biological process; MF, molecular function; CC, cellular component.