Table 5. Univariate analysis and multivariate cox proportional hazards regression analysis of potential risk factors for LFFR, OS, DFFR, DFS.
| Variables | Category | Univariate | Multivariate | |||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| LFFR | OS | DFFR | DFS | LFFR | OS | DFFR | DFS | |||||||||||||||||||||||||
| HR | 95% CI | P | HR | 95% CI | P | HR | 95% CI | P | HR | 95% CI | P | HR | 95% CI | P | HR | 95% CI | P | HR | 95% CI | P | HR | 95% CI | P | |||||||||
| Gender | Male vs. female | 1.85 | 0.46–7.39 | 0.390 | 0.25 | 0.032–1.85 | 0.170 | 0.77 | 0.26–2.26 | 0.64 | 0.66 | 0.26–1.71 | 0.390 | – | – | – | – | – | – | – | – | – | – | – | – | |||||||
| Age | <60 (n=109) vs. ≥60 (n=39) | 4.01 | 1.07–15.00 | 0.039 | 6.28 | 2.31–17.08 | 0.0003 | 1.45 | 0.60–3.52 | 0.41 | 2.20 | 1.10–4.40 | 0.026 | 3.42 | 0.91–12.89 | 0.070 | 4.98 | 1.81–13.67 | 0.0019 | – | – | – | 1.69 | 0.81–3.50 | 0.16 | |||||||
| T stage | T1,2 vs. T3,4 | 3.95 | 0.49–31.67 | 0.200 | 1.58 | 0.51–4.85 | 0.430 | 1.56 | 0.62–3.95 | 0.35 | 2.07 | 0.90–4.76 | 0.088 | – | – | – | – | – | – | – | – | – | – | – | – | |||||||
| N stage | N0,1 vs. N2,3 | 0.39 | 0.10–1.44 | 0.160 | 1.51 | 0.43–5.25 | 0.520 | 3.58 | 0.84–15.23 | 0.08 | 1.22 | 0.53–2.79 | 0.065 | – | – | – | – | – | – | – | – | – | – | – | – | |||||||
| TNM stage | III vs. IVa | 2.78 | 0.69–11.19 | 0.150 | 7.21 | 2.05–25.29 | 0.002 | 3.02 | 1.28–7.10 | 0.01 | 2.80 | 1.38–5.69 | 0.0043 | – | – | – | 4.66 | 1.06–20.41 | 0.041 | 2.86 | 1.22–6.75 | 0.016 | 2.2 | 0.91–5.32 | 0.08 | |||||||
| GTVnx (cm3) | ≤42.7 (n=88) vs. >42.7 (n=60) | 5.98 | 1.23–28.90 | 0.026 | 4.21 | 1.48–12.00 | 0.007 | 1.25 | 0.55–2.83 | 0.59 | 2.04 | 1.03–4.01 | 0.040 | 5.24 | 1.074–25.57 | 0.041 | 1.52 | 0.45–5.21 | 0.500 | – | – | – | 1.14 | 0.50–2.59 | 0.76 | |||||||
| GTVrLNs (cm3) | ≤0.79 (n=66) vs. >0.79 (n=82) | 1.14 | 0.30–4.24 | 0.850 | 0.39 | 0.14–1.11 | 0.076 | 0.62 | 0.28–1.40 | 0.25 | 0.56 | 0.28–1.12 | 0.100 | – | – | – | – | – | – | – | – | – | – | – | – | |||||||
| GTVp (cm3) | ≤42.87 (n=84) vs. >42.87 (n=64) | 5.52 | 1.14–26.70 | 0.034 | 3.93 | 1.38–11.22 | 0.01 | 1.39 | 0.62–3.14 | 0.42 | 2.17 | 1.10–4.30 | 0.026 | – | – | – | – | – | – | – | – | – | – | – | – | |||||||
LFFR, local failure-free rate; OS, overall survival; DFFR, distant failure-free rate; DFS, disease-free survival.