Table 3. Stratified analysis for ALDH2 as risk factor in participants with CMBs by location, sex, drinking and hypertension status.
ALDH2 (*1 vs. *2) | Univariate model | Model 1 | Model 2 | |||||
---|---|---|---|---|---|---|---|---|
OR (95% CI) | P value | OR (95% CI) | P value | OR (95% CI) | P value | |||
Overall | 1.93 (1.21–3.06) | 0.006 | 1.91 (1.17–3.12) | 0.009 | 1.87 (1.14–3.06) | 0.013 | ||
CMBs location | ||||||||
Deep/mixed | 2.56 (1.34–4.89) | 0.005 | 2.55 (1.29–5.05) | 0.007 | 2.53 (1.28–5.03) | 0.008 | ||
Lobar | 1.44 (0.78–2.68) | 0.247 | 1.44 (0.75–2.78) | 0.273 | 1.39 (0.72–2.70) | 0.325 | ||
Sex | ||||||||
Men | 3.26 (1.37–7.75) | 0.008 | 4.43 (1.70–11.49) | 0.002 | 4.51 (1.70–11.97) | 0.003 | ||
Women | 1.53 (0.87–2.71) | 0.140 | 1.29 (0.71–2.34) | 0.401 | 1.28 (0.70–2.34) | 0.429 | ||
Alcohol consumption | ||||||||
Drinking | 2.74 (0.77–9.69) | 0.118 | 2.20 (0.60–8.00) | 0.232 | 1.91 (0.51–7.12) | 0.334 | ||
Non-drinking | 1.94 (1.15–3.26) | 0.013 | 1.77 (1.03–3.06) | 0.040 | 1.76 (1.02–3.04) | 0.044 | ||
Hypertension status | ||||||||
Hypertension | 2.19 (1.20–4.01) | 0.011 | 2.21 (1.18–4.15) | 0.014 | 2.21 (1.17–4.17) | 0.014 | ||
Non-hypertension | 1.39 (0.66–2.93) | 0.393 | 1.51 (0.67–3.39) | 0.323 | 1.52 (0.67–3.43) | 0.318 |
Model 1 was adjusted for sex, age, BMI, smoking, and drinking; model 2 was additionally adjusted for hypertension, DM, and hyperlipidemia. ALDH2, aldehyde dehydrogenase 2; CMBs, cerebral microbleeds; OR, odds ratio; CI, confidence interval; BMI, body mass index; DM, diabetes mellitus.