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. 2020 Mar;8(5):229. doi: 10.21037/atm.2020.01.01

Table 3. Stratified analysis for ALDH2 as risk factor in participants with CMBs by location, sex, drinking and hypertension status.

ALDH2 (*1 vs. *2) Univariate model Model 1 Model 2
OR (95% CI) P value OR (95% CI) P value OR (95% CI) P value
Overall 1.93 (1.21–3.06) 0.006 1.91 (1.17–3.12) 0.009 1.87 (1.14–3.06) 0.013
CMBs location
   Deep/mixed 2.56 (1.34–4.89) 0.005 2.55 (1.29–5.05) 0.007 2.53 (1.28–5.03) 0.008
   Lobar 1.44 (0.78–2.68) 0.247 1.44 (0.75–2.78) 0.273 1.39 (0.72–2.70) 0.325
Sex
   Men 3.26 (1.37–7.75) 0.008 4.43 (1.70–11.49) 0.002 4.51 (1.70–11.97) 0.003
   Women 1.53 (0.87–2.71) 0.140 1.29 (0.71–2.34) 0.401 1.28 (0.70–2.34) 0.429
Alcohol consumption
   Drinking 2.74 (0.77–9.69) 0.118 2.20 (0.60–8.00) 0.232 1.91 (0.51–7.12) 0.334
   Non-drinking 1.94 (1.15–3.26) 0.013 1.77 (1.03–3.06) 0.040 1.76 (1.02–3.04) 0.044
Hypertension status
   Hypertension 2.19 (1.20–4.01) 0.011 2.21 (1.18–4.15) 0.014 2.21 (1.17–4.17) 0.014
   Non-hypertension 1.39 (0.66–2.93) 0.393 1.51 (0.67–3.39) 0.323 1.52 (0.67–3.43) 0.318

Model 1 was adjusted for sex, age, BMI, smoking, and drinking; model 2 was additionally adjusted for hypertension, DM, and hyperlipidemia. ALDH2, aldehyde dehydrogenase 2; CMBs, cerebral microbleeds; OR, odds ratio; CI, confidence interval; BMI, body mass index; DM, diabetes mellitus.