TABLE 2.

Absolute cerebral concentrations and oxygen saturation of hemoglobin in neonates, infants, and children measured with non-invasive FD-NIRS in vivo.

References	Instr.	f (MHz)	Method	# of λ	[Hb] (μM)	[HbO2] (μM)	[HbT] (μM)	StO2 (%)	Age
Watzman et al., 2000	NIM	200	SD: 3 or 4 cm	3	–	–	–	73	0–6 years
Zhao et al., 2005	Own	140	SD: 4 cm	2	16	24	40	59	1–17 days
Franceschini et al., 2007	ISS	110	MD: 1–2.5 cm	7	17	35	52	67	1 week
					14	19	33	57	6 weeks
					21	32	53	61	12 weeks
					24	49	73	67	52 weeks
Grant et al., 2009	ISS	110	MD: 1–2.5 cm	7	21	39	60	65	0–15 days
Roche-Labarbe et al., 2010	ISS	110	MD: 1–2.5 cm	6	12	28	40	70	1 week
					12	18	30	60	6 weeks
Roche-Labarbe et al., 2012	ISS	110	MD: 1–2.5 cm	6	15	40	55	73	1 week
					15	28	43	65	10 weeks
Lin et al., 2013b	ISS	110	MD: 1–2.5 or 1.5–3 cm	6	19	41	60	69	3.6 ± 1.7 weeks
Dehaes et al., 2014	ISS	110	MD: 1–2.5 cm	6	17	45	62	72	0–4 days
Demel et al., 2014b	ISS	110	MD: 1.5–3 cm	2	15	23	38	60	2 days
Dehaes et al., 2015	ISS	110	MD: 1.5–3 cm	6	16	35	51	69	33–71 h
Demel et al., 2015	ISS	110	MD: 1.5–3 cm	2	15	24	39	62	7–71 h (preterm)
					18	30	48	63	7–54 h (term)
Lin P. Y. et al., 2016	ISS	110	MD: 1–2.5 cm	6	–	–	–	50–70	3–14 weeks (preterm)
Farzam et al., 2017	ISS	110	MD: 1.5–3 cm	8	19	41	60	69	2.4 ± 0.8 days (males)
					16	33	50	65	2.6 ± 1.5 days (females)
Ferradal et al., 2017	ISS	110	MD: 1.5–3 cm	8	26	40	66	60	∼4 days (anesthesia)
Schwarz et al., 2018	ISS	110	MD: 1.5-3 cm	2	–	–	–	54	4–13 days

Instr., Instrument; NIM, NIM (Near Infrared Monitoring), Inc. (Philadelphia, PA, United States); ISS, ISS, Inc. (Champaign, IL, United States); SD, single distance; MD, multi distance.