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. 2020 Jan 22;59(14):5595–5601. doi: 10.1002/anie.201913904

Figure 1.

Figure 1

Design of PDEδ PROTAC probes. A, B) Visualization of the PDEδ PROTAC 3 in the binding pocket of PDEδ based on computational modelling (PDB ID: 5ML3). A) The amide C=O forms a hydrogen bond to the backbone NH of Met118. The hydrogen bond is indicated by a dotted line. B) Solvent‐accessible surface of PDEδ around the linker region of PDEδ PROTAC 3. C) Structure and affinity of the pomalidomide‐based PDEδ PROTACs 1–4 and the VHL‐based PROTAC 5. Affinity for PDEδ was determined by competitive fluorescent polarization analysis.