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. 2020 Jan 22;59(14):5595–5601. doi: 10.1002/anie.201913904

Figure 3.

Figure 3

Active PROTAC 3 degrades PDEδ fusion proteins. A) NanoLuc‐expressing HeLa cells were treated with different concentrations of the active PROTAC 3 or inactive PROTAC 4 for 24 h. NanoLuc activity was normalized to the activity of cells that were treated with DMSO. Data are mean values±SD (n=3). B) HEK293T cells, which transiently express mCherry‐PDEδ, were treated with the active PROTAC 3 or inactive PROTAC 4. mCherry intensities were normalized to the DMSO control and related to time 0 (set to 1). C) Representative images from (B) after 24 h of treatment with 1 μm PROTAC 3, PROTAC 4 or DMSO. Scale bar: 100 μm.