Table 1.
Demographic and clinical data of 128 studied patients with a TL in relation the development of hypothyroidism
| All patients (128 patients) n (%) | Hypothyroidism (69 patients) n (%) | No hypothyroidism (59 patients) n (%) | ||
|---|---|---|---|---|
| Gender |
Male Female |
113 (88.3) 15 (11.7) |
58 (84.1) 11 (15.9) |
55 (93.2) 4 (6.8) |
| Age | Median (years), (SD) | 66, (9.3) | 64, (8.7) | 69, (9.4) |
| Location tumor | Hypopharynx | 33 (25.8) | 19 (27.5) | 14 (23.7) |
| Larynx | 95 (74.2) | 50 (72.5) | 45 (76.3) | |
| T Classification | T1 | 9 (7.0) | 1 (1.4) | 8 (13.6) |
|
T2a larynx T2b larynx |
10 (9.4) 4 (3.1) |
6 (8.7) 2 (2.9) |
4 (6.8) 2 (3.4) |
|
| T2 hypopharynx | 12 (9.4) | 4 (5.8) | 8 (13.6) | |
| T3 | 33 (25.8) | 18 (26.1) | 15 (25.4) | |
| T4 | 60 (46.9) | 38 (55.1) | 22 (37.3) | |
| Treatment regimen |
RT‐TL TL‐RT RT‐TL‐RT |
51 (39.8) 55 (43.0) 22 (17.2) |
25 (36.2) 30 (43.5) 14 (20.3) |
26 (44.1) 25 (42.3) 8 (13.6) |
| RT field |
Larynx only Larger |
16 (12.5) 112 (87.5) |
6 (8.7) 63 (91.3) |
10 (16.9) 49 (83.1) |
| (hemi)thyroidectomy | Not performed | 76 (59.3) | 31 (44.9) | 45 (76.3) |
| Performed | 52 (40.6) | 38 (55.1) | 14 (23.7) | |
| Neck dissection | Not performed | 32 (25.0) | 16 (23.2) | 16 (27.1) |
| Performed | 96 (75.0) | 53 (76.8) | 43 (72.9) | |
| Chemotherapy | No concomitant chemotherapy | 105 (82.0) | 57 (82.6) | 48 (81.3) |
| Concomitant chemotherapy with carboplatin/5‐FU | 23 (18.0) | 12 (17.4) | 11 (18.7) | |
Abbreviations: 5‐FU, 5‐Fluorouracil; RT, radiotherapy; TL, total laryngectomy.