Table 3.
Univariable and multivariable Cox regression analysis for development of hypothyroidism
| Variables | Univariable model | Multivariable model | |||
|---|---|---|---|---|---|
| HR (95% CI) | P value | HR (95% CI) | P value | ||
| Treatment regimen |
RT‐TL TL‐RT RT‐TL‐RT |
1 (reference) 0.81 (0.48‐1.39) 1.39 (0.72‐2.68) |
.454 .327 |
1 (reference) 0.49 (0.28‐0.86) 1.78 (0.91‐3.48) |
.014 .090 |
| Tumor site |
Hypopharynx Larynx |
1 (reference) 0.89 (0.52‐1.50) |
.651 |
||
| RT field |
Larynx only (one period) Larger field |
1 (reference) 1.45 (0.58‐3.62) |
.42 |
||
| Chemotherapy |
No concomitant chemotherapy concomitant chemotherapy |
1 (reference) 1.09 (0.59‐2.04) |
.775 |
||
| Neck dissection |
No additional ND Additional ND |
1 (reference) 0.95 (0.54‐1.67) |
.867 |
||
| (Hemi)thyroidectomy |
Not performed Performed |
1 (reference) 2.37 (1.47‐3.82) |
<.001 |
1 (reference) 2.99 (1.81‐4.95) |
<.001 |
| Gender |
Male Female |
1 (reference) 1.51 (0.79‐2.89) |
.208 |
||
| Age (median) | Continuous variable | 0.95 (0.92‐0.98) | <.001 | 0.93 (0.91‐0.96) | <.001 |
Abbreviations: 95% CI, 95% confidence interval; HR, Hazard ratio; ND, neck dissection; RT, radiotherapy. Significant HRs and significant P values are marked in bold font.