Table 3.
Baseline laboratory characteristics and causes of death in deceased subjects with PBC versus non‐PBC
| Parameter | PBC (n = 8) | Non‐PBC (n = 20) | P |
|---|---|---|---|
| Age (years) | 66.5 (54–90) | 72.5 (50–89) | 0.633 |
| Sex (m/f) | 0/8 | 7/13 | 0.172 |
| sp100 or gp210 positive (n) | 1 (12.5%) | 3 (15.0%) | 0.864 |
| Total cholesterol (mmol L−1) | 6.4 (6.1–6.6) | 5.4 (1.9–9.0) | 0.193 |
| Fasting glucose (mmol L−1) | 4.3 (3.5–6.3) | 6.0 (4.0–10.9) | 0.065 |
| Total bilirubin (µmol L−1) | 6.8 (5.1–37.6) | 11.1 (5.1–85.5) | 0.633 |
| ALT (×ULN) | 0.8 (0.4–2.5) | 0.6 (0.3–2.1) | 0.633 |
| ALP (×ULN) | 1.6 (1.4–6.0) | 0.7 (0.3–3.6) | 0.065 |
| GGT (×ULN) | 2.3 (0.6–24.4) | 1.8 (0.5–18.0) | 0.633 |
| IgM (×ULN) | 1.1 (0.6–2.3) | 0.6 (0.1–1.0) | 0.065 |
| Ferritin (pmol L−1) | 195.5 (92.1–294.4) | 561.8 (62.9–5610.8) | 0.193 |
| Prothrombin index (%) | 100 (88–122) | 97 (16–112) | 0.633 |
| Platelet count (×109 per L) | 229.5 (165–369) | 225 (60–616) | 0.633 |
| Cause of death | |||
| CV events incl. stroke | n = 0 | n = 8 | |
| Nonhepatic malignancies | n = 1 | n = 5 | |
| Liver‐related events | n = 1 | n = 4 | |
| Not available | n = 6 | n = 3 | |
ALP, alkaline phosphatase; ALT, alanine aminotransferase; BMI, body mass index; CV events, cardiovascular events; GGT, gamma‐glutamyl transpeptidase; IgM, immunoglobulin M; PBC, primary biliary cholangitis; ULN, upper limit of normal.
Data shown as median (range in brackets). Levels of significance: *P < 0.05; **P < 0.001 (Mann–Whitney U test, chi‐square test; P‐values adjusted for multiple testing by Benjamini–Hochberg procedure).