Summary of findings for the main comparison. Nonsteroidal anti‐inflammatory drugs for paediatric tonsillectomy.
| Nonsteroidal anti‐inflammatory drugs for paediatric tonsillectomy | ||||||
| Patient or population: patients with paediatric tonsillectomy Settings: Intervention: nonsteroidal anti‐inflammatory drugs | ||||||
| Outcomes | Illustrative comparative risks* (95% CI) | Relative effect (95% CI) | No of Participants (studies) | Quality of the evidence (GRADE) | Comments | |
| Assumed risk | Corresponding risk | |||||
| Control | Nonsteroidal anti‐inflammatory drugs | |||||
| Perioperative bleeding requiring surgical intervention | Moderate1 | OR 1.69 (0.71 to 4.01) | 1044 (14 studies) | ⊕⊕⊕⊝ moderate2 | ||
| 20 per 1000 | 33 per 1000 (14 to 76) | |||||
| Perioperative bleeding requiring non‐surgical intervention | Moderate1 | OR 0.99 (0.41 to 2.4) | 745 (10 studies) | ⊕⊕⊕⊝ moderate2 | ||
| 50 per 1000 | 50 per 1000 (21 to 112) | |||||
| Vomiting | Moderate3 | RR 0.72 (0.61 to 0.85) | 1021 (13 studies) | ⊕⊕⊕⊕ high | ||
| 357 per 1000 | 257 per 1000 (218 to 303) | |||||
| *The basis for the assumed risk (e.g. the median control group risk across studies) is provided in footnotes. The corresponding risk (and its 95% confidence interval) is based on the assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI). CI: Confidence interval; RR: Risk ratio; OR: Odds ratio; | ||||||
| GRADE Working Group grades of evidence High quality: Further research is very unlikely to change our confidence in the estimate of effect. Moderate quality: Further research is likely to have an important impact on our confidence in the estimate of effect and may change the estimate. Low quality: Further research is very likely to have an important impact on our confidence in the estimate of effect and is likely to change the estimate. Very low quality: We are very uncertain about the estimate. | ||||||
1 Based on Marret 2003. 2 Confidence interval crosses no effect and is inconsistent with an increased risk of bleeding. 3 Median control group risk from included studies.