Sutherland 1998.

Methods	Randomized, parallel group trial
Participants	50 children undergoing elective tonsillectomy and/or adenoidectomy, myringotomy or submucous diathermy of inferior turbinates (SMIT) ASA I‐II Age 3‐10 years (mean 6.2, 5.8) Sex distribution: M/F (12/13, 13/11) Country: UK
Interventions	Tenoxicam 0.75 mg/kg intramuscularly at induction Morphine 0.2 mg/kg intramuscularly at induction
Outcomes	Blood loss requiring surgical intervention Pain (measured rescue analgesia) Vomiting
Notes	Study originally designed to look at pain. One withdrawal from morphine group included in our analysis so an ITT analysis could be performed.
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Described as randomized but no further details given
Allocation concealment (selection bias)	Unclear risk	Sealed envelopes used but no further details given
Baseline Imbalances All outcomes	Unclear risk	Demographic data comparable. But no details given of surgery type
Blinding of participants and personnel (performance bias) 1. Perioperative bleeding requiring surgical intervention	Unclear risk	Unclear if surgeon blinded
Blinding of participants and personnel (performance bias) 2.Perioperative bleeding requiring non‐surgical intervention	Unclear risk	N/a
Blinding of participants and personnel (performance bias) 3. Vomiting	Low risk	Nursing staff blinded
Blinding of outcome assessment (detection bias) 1. Perioperative bleeding requiring surgical intervention	Unclear risk	Unclear who is assessing patients
Blinding of outcome assessment (detection bias) 2. Perioperative bleeding requiring non‐surgical intervention	Unclear risk	N/a
Blinding of outcome assessment (detection bias) 3. Vomiting	Low risk	Nurses assessing patients were blinded
Incomplete outcome data (attrition bias) All outcomes	Low risk	Data for excluded child included in order to follow ITT principle
Selective reporting (reporting bias)	Low risk	All expected outcomes reported
Other bias All outcomes	High risk	Tenoxicam group required more morphine. Could affect vomiting results