Loirat 1988.

Methods	Country: France Recruitment: Multicentre study (19 units) involving French Society of Paediatric Nephrology Random allocation: yes, stratified by centre Eligibility criteria: Yes Baseline characteristics of participants: Similar Blinding ‐ subjects: NS ‐ assessors: NS ‐ therapists: NS Intention‐to‐treat analysis: Yes Follow‐up: 100% (short‐term); ˜ 75% (12 months)
Participants	Inclusion criteria Median age: 19 months (range 2 months to 13 years) Sex: 40 males Treatment group Number: 39 Control group Number: 40
Interventions	Treatment group FFP 10 mL/kg/d for 7 days plus supportive care Control group Supportive care only Supportive care was similar in both groups (PD if indicated)
Outcomes	All‐cause mortality ESKD (dialysis‐dependent at 6 weeks) Proteinuria at last follow‐up Hypertension at last follow‐up
Notes	HUS study Diarrhoea prodrome: 87%
Risk of bias
Bias	Authors' judgement	Support for judgement
Allocation concealment?	Low risk	A ‐ Adequate