Perez 1998.

Methods	Country: Argentina Recruitment: Single tertiary care paediatric hospital. Randomised: Computer‐ generated Inclusion criteria participants: yes Baseline characteristics: Similar Blinding ‐ subject: Yes ‐ therapist: No ‐ assessor: Yes Placebo controlled: Yes Intention‐to‐treat analysis: No Follow‐up: 98% (2 weeks)
Participants	Inclusion criteria Sex: 48 males Median age: 13 months (range 9‐23) Groups were similar at study entry (age, sex, seizure history, haematology, biochemistry) Treatment group Number: 45 Control group Number: 47
Interventions	Treatment group Methylprednisolone (5 mg/kg/d), 4 times a day for 7 days Supportive care Control group Placebo (matched for colour, flavour appearance) Supportive care Supportive interventions similar in both groups (type of dialysis not specified)
Outcomes	All‐cause mortality Neurological event Adverse events: peritonitis
Notes	HUS study Diarrhoea‐associated HUS (100%)
Risk of bias
Bias	Authors' judgement	Support for judgement
Allocation concealment?	Low risk	A ‐ Adequate