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. 2010 Jan 20;2010(1):CD003469. doi: 10.1002/14651858.CD003469.pub4

Corry 1997.

Methods Double blind randomised controlled trial comparing BoNT‐A injections with injections of normal saline. Randomisation was restricted to ensure 7 patients in each group. One of 14 envelopes containing the instruction "placebo" or "botulinum" was drawn for each patient and opened by the non‐blind injector just before injection. Allocation concealment not clearly stated. Outcome assessors and participants were blinded. Follow up at 2 and 12 weeks.
Participants 14 children (5 male, 9 female; mean age 9 years) (n=7 Treatment, n=7 Control) with a dynamic component to spasticity ‐ 12 hemiplegia, 1 quadriplegia, and 1 triplegia. Three had previous upper limb surgery. No dropouts reported.
Interventions Treatment Group (BoNT‐A alone) 
 Refer to Table 14
Control (placebo) 
 Intramuscular injection of saline.
Outcomes Active ROM of MCP, wrist and elbow extension; thumb in palm position for both thumb extension and abduction; Ashworth scale for thumb, wrist, and elbow tone; wrist resonance frequency (tone); grasp and release of an empty film capsule scored using a modified Reddihough scale and the number of transfers of a coin.
Notes The authors were contacted and generously provided assistance, however no additional data were available.
Risk of bias
Bias Authors' judgement Support for judgement
Allocation concealment? Unclear risk B ‐ Unclear