| Nitroderivatives for chronic asymptomatic Trypanosoma cruzi infection |
|
Patient or population: people with chronic asymptomatic Trypanosoma cruzi infection
Intervention: nitroderivatives |
| Outcomes |
Illustrative comparative risks* (95% CI) |
Relative effect
(95% CI) |
No of participants
(studies) |
Quality of the evidence
(GRADE) |
| Assumed risk |
Corresponding risk |
|
Control |
Nitroderivatives |
|
ECG Abnormalities ‐ RCT data ‐ benznidazole |
Study population |
OR 0.41
(0.07 to 2.31) |
235
(2 studies) |
⊕⊕⊝⊝
low
|
| 43 per 1000 |
18 per 1000
(3 to 94) |
| Moderate |
| 41 per 1000 |
17 per 1000
(3 to 90) |
|
Progression of cardiomyopathy: non‐RCT data ‐ adults ‐ nitroderivatives
Emergence of substantial changes in the diagnostic tests or clinical status, or both (see text) |
Study population |
OR 0.74
(0.32 to 1.73) |
986
(4 studies) |
⊕⊝⊝⊝
very low
|
| 118 per 1000 |
90 per 1000
(41 to 187) |
| Moderate |
| 116 per 1000 |
89 per 1000
(40 to 185) |
|
Mortality: non‐RCT data ‐ adults ‐ nitroderivatives
All‐cause mortality |
Study population |
OR 0.55
(0.26 to 1.14) |
3396
(6 studies) |
⊕⊝⊝⊝
very low
|
| 44 per 1000 |
25 per 1000
(12 to 50) |
| Moderate |
| 55 per 1000 |
31 per 1000
(15 to 62) |
| *The basis for the assumed risk (e.g. the median control group risk across studies) is provided in footnotes. The corresponding risk (and its 95% confidence interval) is based on the assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI).
CI: confidence interval; ECG: electrocardiogram; OR: odds ratio; RCT: randomised controlled trial. |
| GRADE Working Group grades of evidence
High quality: Further research is very unlikely to change our confidence in the estimate of effect.
Moderate quality: Further research is likely to have an important impact on our confidence in the estimate of effect and may change the estimate.
Low quality: Further research is very likely to have an important impact on our confidence in the estimate of effect and is likely to change the estimate.
Very low quality: We are very uncertain about the estimate. |
