Comparison 2. Patient‐related outcomes: efficacy.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 ECG abnormalities ‐ RCT data ‐ benznidazole	2	235	Odds Ratio (M‐H, Random, 95% CI)	0.41 [0.07, 2.31]
2 Progression of cardiomyopathy: non‐RCT data ‐ adults, nitroderivatives	4	986	Odds Ratio (M‐H, Random, 95% CI)	0.74 [0.32, 1.73]
3 Mortality: non‐RCT data ‐ adults, all tested drugs	6	3396	Odds Ratio (M‐H, Random, 95% CI)	0.55 [0.26, 1.14]
3.1 Nitroderivatives	6	2419	Odds Ratio (M‐H, Random, 95% CI)	0.66 [0.28, 1.56]
3.2 Allopurinol	1	977	Odds Ratio (M‐H, Random, 95% CI)	0.28 [0.11, 0.72]