| 1 BZD mild‐to‐moderate ‐ RCT data only |
2 |
3651 |
Odds Ratio (M‐H, Random, 95% CI) |
3.84 [1.74, 8.44] |
| 1.1 Pruritus |
1 |
709 |
Odds Ratio (M‐H, Random, 95% CI) |
3.83 [2.41, 6.08] |
| 1.2 Mild rash |
1 |
709 |
Odds Ratio (M‐H, Random, 95% CI) |
7.59 [4.79, 12.03] |
| 1.3 Moderate rash |
1 |
709 |
Odds Ratio (M‐H, Random, 95% CI) |
7.78 [4.15, 14.61] |
| 1.4 Unspecified |
1 |
106 |
Odds Ratio (M‐H, Random, 95% CI) |
13.53 [0.74, 246.49] |
| 1.5 Headache |
1 |
709 |
Odds Ratio (M‐H, Random, 95% CI) |
1.22 [0.85, 1.75] |
| 1.6 Insomnia |
1 |
709 |
Odds Ratio (M‐H, Random, 95% CI) |
2.08 [0.88, 4.92] |
| 3 BZD severe side effects |
3 |
9208 |
Odds Ratio (M‐H, Random, 95% CI) |
12.02 [6.07, 23.80] |
| 3.1 Toxic hepatitis |
2 |
1507 |
Odds Ratio (M‐H, Random, 95% CI) |
15.19 [1.84, 125.09] |
| 3.2 Arthritis |
1 |
709 |
Odds Ratio (M‐H, Random, 95% CI) |
10.41 [1.33, 81.75] |
| 3.3 Peripheral neuropathy |
2 |
1507 |
Odds Ratio (M‐H, Random, 95% CI) |
11.69 [2.07, 66.19] |
| 3.4 Lymphadenopathy |
1 |
709 |
Odds Ratio (M‐H, Random, 95% CI) |
19.77 [1.15, 341.06] |
| 3.5 Oedema |
1 |
709 |
Odds Ratio (M‐H, Random, 95% CI) |
4.02 [1.48, 10.88] |
| 3.6 Fever |
2 |
1275 |
Odds Ratio (M‐H, Random, 95% CI) |
10.35 [1.87, 57.36] |
| 3.7 Severe skin reactions |
2 |
1396 |
Odds Ratio (M‐H, Random, 95% CI) |
142.68 [19.64, 1036.38] |
| 3.8 Severe gastrointestinal intolerance |
2 |
1396 |
Odds Ratio (M‐H, Random, 95% CI) |
15.36 [1.86, 126.55] |
| 5 ALLOP ‐ mild‐to‐moderate ‐ RCT data only |
2 |
355 |
Odds Ratio (M‐H, Random, 95% CI) |
1.89 [0.74, 4.85] |
| 5.1 Pyrosis |
1 |
35 |
Odds Ratio (M‐H, Random, 95% CI) |
4.27 [0.20, 89.72] |
| 5.2 Vertigo |
1 |
35 |
Odds Ratio (M‐H, Random, 95% CI) |
0.16 [0.01, 4.32] |
| 5.3 Rash |
2 |
75 |
Odds Ratio (M‐H, Random, 95% CI) |
2.23 [0.41, 12.19] |
| 5.4 Leukopenia |
1 |
35 |
Odds Ratio (M‐H, Random, 95% CI) |
2.91 [0.13, 65.53] |
| 5.5 Lymph node increase |
1 |
35 |
Odds Ratio (M‐H, Random, 95% CI) |
1.67 [0.06, 44.05] |
| 5.6 Vomit |
1 |
35 |
Odds Ratio (M‐H, Random, 95% CI) |
1.67 [0.06, 44.05] |
| 5.7 Stomach ache |
1 |
35 |
Odds Ratio (M‐H, Random, 95% CI) |
1.67 [0.06, 44.05] |
| 5.8 Red Eye |
1 |
35 |
Odds Ratio (M‐H, Random, 95% CI) |
1.67 [0.06, 44.05] |
| 5.9 Pruritus |
1 |
35 |
Odds Ratio (M‐H, Random, 95% CI) |
4.27 [0.20, 89.72] |
| 6 ALLOP ‐ severe side effects |
4 |
2298 |
Odds Ratio (M‐H, Random, 95% CI) |
12.34 [3.23, 47.04] |
| 6.1 Skin severe reactions |
3 |
1286 |
Odds Ratio (M‐H, Random, 95% CI) |
12.42 [2.17, 71.02] |
| 6.2 Fever |
1 |
35 |
Odds Ratio (M‐H, Random, 95% CI) |
7.43 [0.38, 146.72] |
| 6.3 Severe gastrointestinal effects |
1 |
977 |
Odds Ratio (M‐H, Random, 95% CI) |
19.69 [1.06, 366.94] |
| 7 NFTMX ‐ severe side effects |
1 |
3056 |
Odds Ratio (M‐H, Random, 95% CI) |
81.75 [18.97, 352.35] |
| 7.1 Polyneuritis |
1 |
764 |
Odds Ratio (M‐H, Random, 95% CI) |
35.37 [1.69, 742.39] |
| 7.2 Toxic hepatitis |
1 |
764 |
Odds Ratio (M‐H, Random, 95% CI) |
179.83 [10.50, 3079.04] |
| 7.3 Malaise |
1 |
764 |
Odds Ratio (M‐H, Random, 95% CI) |
96.03 [5.36, 1718.90] |
| 7.4 Severe skin reactions |
1 |
764 |
Odds Ratio (M‐H, Random, 95% CI) |
65.04 [3.47, 1217.89] |
| 8 ITRA ‐ severe side effects |
1 |
300 |
Odds Ratio (M‐H, Random, 95% CI) |
3.69 [0.15, 91.35] |
| 9 Drug discontinuation ‐ all populations, all drugs |
10 |
4385 |
Odds Ratio (M‐H, Random, 95% CI) |
11.84 [3.14, 44.70] |
| 9.1 RCT data |
5 |
1056 |
Odds Ratio (M‐H, Random, 95% CI) |
2.65 [0.40, 17.66] |
| 9.2 Non‐RCT data |
5 |
3329 |
Odds Ratio (M‐H, Random, 95% CI) |
42.48 [13.78, 130.95] |
