Viotti 2006*.

Methods	Non‐randomised study
Participants	Adults
Interventions	BZD (n = 294) 5 mg/kg/day (4 weeks) Untreated (n = 304)
Outcomes	Serology status Side effects Progression of cardiomyopathy Mortality
Notes	Argentina 2006 Refer to study as subgroup of reported cohort
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	High risk
Allocation concealment (selection bias)	High risk
Blinding of participants and personnel (performance bias) All outcomes	High risk
Blinding of outcome assessment (detection bias) All outcomes	Low risk
Incomplete outcome data (attrition bias) All outcomes	High risk

ALLOP: allopurinol; BZD: benznidazole; ECG: electrocardiogram; ITRA: itraconazole; NFTMX: nifurtimox; PCR: polymerase chain reaction; RCT: randomised controlled trial.