| Methods |
Cross‐over, "double‐blind" ‐ no details
13/21 LTFU |
| Participants |
Autism or PDD‐NOS (DSM‐IV) all male, 3‐8 yrs |
| Interventions |
Treatment: synthetic secretin 2CU/kg baseline or week 4 |
| Outcomes |
Aberrant Behaviour Checklist |
| Notes |
Reliable Change Index to assess treatment effect, MANOVA. High loss to follow‐up (62%). Low sample size |
| Risk of bias |
| Bias |
Authors' judgement |
Support for judgement |
| Random sequence generation (selection bias) |
Unclear risk |
Insufficient information |
| Allocation concealment (selection bias) |
Unclear risk |
Insufficient information |
| Blinding (performance bias and detection bias)
All outcomes |
Unclear risk |
"Double‐blind" but no details |
| Incomplete outcome data (attrition bias)
All outcomes |
High risk |
62% loss to follow‐up |
