Table 1.
Vaccination and Challenge Regimes
| Group | Initial Vaccination (Dose) | Boost Vaccination (Dose) | Challenge Dose (vp of RHV) |
|---|---|---|---|
| ChAd‐NS (1E6 challenge) | ChAd‐NS (1 × 108 i.u.) | ‐ | 1 × 106 vp |
| ChAd‐NS (1E5 challenge) | ChAd‐NS (1 × 108 i.u.) | ‐ | 1 × 105 vp |
| ChAd‐NS (single high dose) | ChAd‐NS (6.8 × 108 i.u.) | ‐ | 1 × 105 vp |
| ChAd‐NS/ChAd‐NS | ChAd‐NS (1 × 108 i.u.) | ChAd‐NS (1 × 108 i.u.) | 1 × 105 vp |
| ChAd‐NS/DNA | ChAd‐NS (1 × 108 i.u.) | DNA (100 µg) | 1 × 105 vp |
| Mock vaccination | ChAd‐GFP (1 × 108 i.u.) | ‐ | 105 or 106 vp |