Figure 4.

CDmiR‐222 levels in bile at 2 h of normothermic machine perfusion (NMP) are predictive of hepato‐cholangiocellular injury and function at end of NMP. Relative CDmiR‐222 (open circles) values, but not relative HDmiR‐122 values (closed circles), at 2 h of NMP correlated with peak aspartate aminotransferase (AST) in perfusate (A), and with lactate dehydrogenase (LDH) in bile (B) at 6 h of NMP (6 h NMP). In the case of bicarbonate in bile at 6 h NMP, also only CDmiR‐222, and not HDmiR‐122, at 2 h showed a strong, but negative, correlation (C), while both miRs were predictive of the bile/perfusate glucose ratio at 6 h (D). Spearman's correlation coefficient (r) and P‐value are indicated