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. 2019 Dec 12;20(4):1014–1027. doi: 10.1111/ajt.15654

Figure 6.

Figure 6

The GMS was associated with inverse Simpson index and could predict aGVHD. Inverse Simpson index was higher in the low GMS group compared with the high GMS group both in discovery set (P = .001, 4A) and validation set (P < .001, 4B). Receiver operating characteristic (ROC) curves show the predictive performance of GMS and inverse Simpson index for estimating grade II‐IV aGVHD (C and D). The results of the bootstrap (n = 2000) test for the two ROC curves indicate that the AUC of the sum of GMS was significantly higher than those of the inverse Simpson index both in discovery set (0.904 vs 0.622, P < .001) and validation set (0.887 vs 0.673, P = .005). Similarly, ROC curves of the GMS showed the predictive performance in the discovery and validation cohorts for estimating grade III‐IV aGVHD, respectively (AUC = 0.808 and 0.860; P < .001 and = .001, respectively; E and F). AUC, area under the ROC curve; GMS, gut microbiota score; ROC, receiver operating characteristic [Color figure can be viewed at https://www.wileyonlinelibrary.com]