Table 3.
SNP Analysis
| Gene | SNP | Genotype | N | Motor* | P | N | Functional* | P | N | Cognitive* | P |
|---|---|---|---|---|---|---|---|---|---|---|---|
| TLR4 | rs1927914 (G/A) | A/A | 337 | 5.15 (6.56) | 0.039a | 337 | −0.92 (1.53) | 0.828 | 323 | −11.50 (24.88) | 0.686 |
| G carriers | 473 | 3.89 (7.05) | 473 | −0.85 (1.32) | 212 | −12.04 (24.61) | |||||
| TLR4 | rs1927911 (A/G) | G/G | 431 | 4.94 (7.07) | 0.05a | 431 | 0.90 (1.50) | 276 | −12.18 (26.98) | 0.828 | |
| A carriers | 379 | 3.82 (6.91) | 380 | −0.85 (1.31) | 0.511 | 257 | −11.62 (22.05) | ||||
| TLR4 | rs10116253 (T/C) | T/T | 434 | 4.80 (6.79) | 0.087 | 434 | −0.90 (1.49) | 0.604 | 281 | −11.96 (25.29) | 0.547 |
| C carriers | 377 | 3.92 (7.21) | 377 | −0.86 (1.31) | 255 | −11.52 (23.57) | |||||
| TREM2 |
rs75932628 (H47R ‐ C/T) |
C/C | 817 | 4.47 (7.01) | 0.914 | 817 | −0.87 (1.40) | 0.138 | 539 | −11.74 (24.88) | 0.018a |
| T carriers | 13 | 4.69 (11.79) | 13 | −1.25 (2.02) | 9 | −28.36 (26.47) |
*
Median change (standard error of the ratio change of points/years).
SNP, single nucleotide polymorphism.