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. 2020 Jan 28;59(14):5505–5509. doi: 10.1002/anie.201908063

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© 2020 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Scheme 2 — Triple O‐phosphorylated 1‐aminopyrene trisulfonamides: a) ClSO₃H, 65 °C, 3 h; b) 5, Et₃N, MeCN, r.t., overnight; c) CF₃CO₂H, r.t., 1 h, then 1 m aq. Et₃N/H₂CO₃ (pH 8–9), overnight; d) CH₃NHCH₂CH₂OH, aq. MeCN, r.t., overnight; e) (CF₃CO)₂O, CH₂Cl₂, Et₃N, then CH₃I, Cs₂CO₃, DMF, 70 °C, 40 min; f) MeOH, NaHCO₃; g) aq. NaOH, MeOH, r.t.; h) POCl₃, (MeO)₃PO, r.t., 3 h, then aq. Et₃N/H₂CO₃ buffer (pH 8–9), overnight.