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. 2020 Jan 28;59(14):5505–5509. doi: 10.1002/anie.201908063

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© 2020 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Scheme 3 — Triple O‐phosphorylated 1,3,6‐tris[(3‐hydroxypropyl)sulfonyl]‐pyrene‐8‐amine 16: a) HS(CH₂)₃OH, DIPEA, Pd₂(dba)₃, XantPhos, DMF, 100 °C, overnight; b) aq. H₂O₂, Na₂WO₄, AcOH, r.t., overnight; c) aq. NaOH, MeOH; d) POCl₃, (MeO)₃PO, r.t., then aq. Et₃N/H₂CO₃ buffer (pH 8–9); e) CH₃I, Cs₂CO₃, DMF.