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. 2020 Feb 5;34(4):e195–e197. doi: 10.1111/jdv.16114

Figure 2.

Figure 2

NAGED, but not pioglitazone, partially reverses experimentally induced EMT in ‘clinically healthy’ HFs ex vivo. (a–d) Quantitative analyses and corresponding representative images of Vimentin (a), and SLUG (b) positive cells, E‐cadherin expression (c) and K15 positive cells (d) in the bulge of healthy HFs treated ex vivo with vehicle (VEH), EMT cocktail (VEH‐EMT), EMT cocktail and 0.01 mmol/L NAGED (EMT‐NAGED), or EMT cocktail and 0.01 mmol/L Pioglitazone (EMT‐PIO). Data are expressed as fold change of mean ± SEM over VEH‐EMT, N = 13–26 HFs/group from 2 to 3 different healthy donors. Graph Pad Prism 6, Kruskal–Wallis test, P < 0.0001, followed by Dunn's multiple comparisons test, # P < 0.05, ## P < 0.01, ### P < 0.001, #### P < 0.0001. Scale bars: 100 μm.