Table 1.

TLS‐risk‐stratification based on CLL tumour burden Seymour et al. (2018).

TLS‐risk	Tumour burden assessment
Low	All LN < 5 cm in diameter AND ALC < 25 × 109/l
Medium*	Any LN ≥ 5–<10 cm in diameter OR ALC ≥ 25 × 109/l
High	Any LN ≥ 10 cm OR ALC ≥ 25 × 109/l AND Any LN ≥ 5 cm in diameter

ALC, absolute lymphocyte count; CLL, chronic lymphocytic leukaemia; LN, lymph node; TLS, tumour lysis syndrome.

^*Patients with medium TLS‐risk who have creatinine clearance of <80 mg/ml are to be managed as high‐risk.