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. 2020 Jan 23;287(6):1058–1075. doi: 10.1111/febs.15205

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© 2020 The Authors. The FEBS Journal published by John Wiley & Sons Ltd on behalf of Federation of European Biochemical Societies

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Model of age‐related changes at the NPC during yeast replicative aging 11. (A) Summary of nuclear transport‐related changes occurring in replicative aging baker's yeast cell, as measured in 2, 11, 13: (a) The abundance of indicated FG‐Nups and proteins assisting in NPC assembly declines with replicative aging, (b) aged cells more frequently have NE herniations, and (c) nucleocytoplasmic exchange is decreased in aged cells. (B) Schematic representation of NPC assembly and nuclear transport dynamics in young cells based on 68, 69, 83. (C) Model: In aged cells, the decrease in the abundance of several proteins that assist in NPC assembly (indicated by faded cartoons) causes the accumulation of misassembled NPCs in aged mother cells. Misassembled NPCs are covered with membrane and do not participate in nucleocytoplasmic exchange. In other words, the overall number of transport competent NPCs is reduced in replicative aged mother cells.