Table 2.
Associations between platelet count (PC), urine albumin/creatinine ratio (UACR) and C‐reactive protein (CRP) and WHO grade ≥1 and grade 2 bleeding on the same day the blood and urine samples were taken (A) and 24 h after sampling (B). The odds ratio for bleeding by platelet count, urine albumin/creatinine ratio and CRP is for every doubling of the respective measurement. For platelet count an odds ratio <1 means that the probability a bleeding occurs is higher with decreasing platelet count. For urine albumin/creatinine ratio and CRP an odds ratio >1 means the probability of a bleeding occurring is higher with increasing values for urine albumin/creatinine ratio and CRP.
| (A) | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| WHO grade ≥1 bleeding on the day of the measurement | WHO grade 2 bleeding on the day of the measurement | |||||||||||
| Univariate analysis | Analysis adjusted for PC | Univariate analysis | Analysis adjusted for PC | |||||||||
| Odds ratio per doubling of variable | 95% CI | P‐value | Odds ratio per doubling of variable | 95% CI | P‐value | Odds ratio per doubling of variable | 95% CI | P‐value | Odds ratio per doubling of variable | 95% CI | P‐value | |
| PC | 0·68 (n = 1708 total days of observation, n = 507 bleeding days) | (0·60–0·77) | <0·001 | 0·94* (n = 1708 total days of observation, n = 147 bleeding days) | (0·78–1·13) | 0·527 | ||||||
| UACR | 1·13* (n = 438 total days of observation, n = 135 bleeding days) | (1·01–1·26) | 0·027 | 1·12* (n = 429, n = 133 bleeding days) | (1·01–1·26) | 0·037 | 1·14 (n = 438 total days of observation, n = 42 bleeding days) | (0·95–1·36) | 0·157 | 1·14 (n = 429, n = 41 bleeding days) | (0·95–1·36) | 0·150 |
| CRP | 1·21 (n = 462 total days of observation, n = 137 bleeding days) | (1·07–1·37) | 0·002 | 1·18 (n = 447, n = 135 bleeding days) | (1·04–1·35) | 0·012 | 1·25 (n = 462 total days of observation, n = 50 bleeding days) | (1·03–1·52) | 0·027 | 1·31 (n = 447, n = 48 bleeding days) | (1·06–1·62) | 0·012 |
| (B) | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| WHO grade ≥1 bleeding 24 h after the measurement | WHO grade 2 bleeding 24 h after the measurement | |||||||||||
| Univariate analysis | Analysis adjusted for PC | Univariate analysis | Analysis adjusted for PC † | |||||||||
| Odds ratio per doubling of variable | 95% CI | P‐value | Odds ratio per doubling of variable | 95% CI | P‐value | Odds ratio per doubling of variable | 95% CI | P‐value | Odds ratio per doubling of variable | 95% CI | P‐value | |
| PC | 0·71 (n = 1598 total days of observation, n = 474 bleeding days) | (0·63–0·91) | <0·001 | 0·87 (n = 1598 total days of observation, n = 142 bleeding days) | (0·72–1·06) | 0·161 | ||||||
| UACR | 1·15* (n = 409 total days of observation, n = 125 bleeding days) | (1·04–1·29) | 0·009 | 1·16* (n = 402, n = 122 bleeding days) | (1·04–1·29) | 0·010 | 1·23* (409 total days of observation, n = 43 bleeding days) | (1·05–1·44) | 0·012 | 1·24* (n = 402, n = 41 bleeding days) | (1·05–1·46) | 0·010 |
| CRP | 1·12 (n = 435 total days of observation, n = 129 bleeding days) | (0·99–1·27) | 0·066 | 1·13 (n = 422, n = 124 bleeding days) | (1·04–1·60) | 0·076 | 1·20* (n = 435 total days of observation, n = 49 bleeding days) | (0·99–1·45) | 0·058 | 1·29* (n = 422, n = 45 bleeding days) | (1·04–1·60) | 0·020 |
Model run with only one random intercept due to low number of patients contributing more than one on‐protocol episode.
After correcting for PC, fever and vascular risk the odds ratio for UACR is 1·27, (n = 362, n = 39 bleeding days), 95% CI 1·06–1·52, P‐value 0·009 and the odds ratio for CRP is 1·39, (n = 372, n = 40 bleeding days), 95% CI 1·08–1·78, P‐value 0·012.