Table 1.

Standard Protocol Items: Recommendation for Interventional Trials (SPIRIT) schedule of enrollment, interventions, and assessments.

Protocol items		Study period
		Screening (day -3 to -1)	Enrollment (day 0)	Assessment and allocation (day 0)	Study diets (days 2-7)	First follow-up (days 14±3)	Second follow-up (days 21±3)
Enrollment
	Eligibility screen		x
	Informed consent		x
	Randomization and allocation			x
Interventions
	Different diets			x	x
Assessments
	Demographics	x
	Comorbidities	x
	Physical examinations	x			x	x	x
Primary outcome
	Resolution of diarrhea (by day 5)				x
Secondary outcomes
	Resolution of diarrhea (by day 7)				x
	Consistency of stool				x
	Frequency of stool				x
	Recovery time				x
	Hospital-acquired infection				x
	Relapse at first follow-up					x
	Relapse at second follow-up						x
	Enteric pathogen detection by TaqMan assaya	x
	Detection of gut microbiota by 16S rRNA sequencinga		x		x
	Detection of proteomes and metabolomes from blooda		x		x

^aAccording to the addendum (Ethical Committee approval on May 5, 2018), at the end of the study, stored stool samples and blood samples will be processed for the desired testing.