Table 3.

Significant toxicities

	Any grade			Grade 3 or greater
	Normal renal function (n = 63)	Renal dysfunction (n = 48)	p-Valuea	Normal renal function (n = 63)	Renal dysfunction (n = 48)	p-Valuea
CV	31 (49%)	31 (65%)	0.12	10 (16%)	16 (33%)	0.042
Peripheral edema	17 (27%)	14 (29%)	0.83	-	-
Hypotension	10 (l6%)	7 (l5%)	1.0	6 (10%)	5 (10%)	1.0
Hypertension	8 (l3%)	13 (27%)	0.085	3 (5%)	6 (l3%)	0.17
Tachycardia	1 (2%)	6 (13%)	0.041	-	1 (2%)	0.43
Heart failure	-	4 (8.3%)	0.033	-	4 (8.3%)	0.033
Atrial fibrillation	6 (l0%)	7 (15%)	0.55	1 (2%)	3 (6%)	0.31
Chest pain	3 (5%)	3 (6%)	1.0	1 (2%)	-	1.0
MI	-	2 (4%)	0.19	-	2 (4%)	0.19
CNS	46 (73%)	43 (90%)	0.033	7 (11%)	7 (15%)	0.77
Fatigue	37 (59%)	35 (73%)	0.16	7 (11%)	5 (10%)	1.0
Fever	7 (11%)	5 (l0%)	1.0	-	-
Insomnia	7 (11%)	4 (8%)	0.75	-	-
ICH	1 (2%)	3 (6%)	0.31	-	1 (2%)	0.43
AMS	1 (2%)	1 (2%)	1.0	-	-
Confusion	5 (8%)	5 (l0%)	0.74	1 (2%)	1 (2%)	1.0
Dizziness	7 (11%)	13 (27%)	0.045	2 (3%)	1 (2%)	1.0
Respiratory	39 (62%)	37 (77%)	0.10	9 (l4%)	19 (40%)	0.0037
Cough	15 (24%)	l4 (29%)	0.29	-	-
Dyspnea	24 (38%)	24 (50%)	0.25	4 (6%)	6 (13%)	0.32
Pharyngitis	3 (5%)	6 (l3%)	0.17	-	-
Respiratory hemorrhage	1 (2%)	-	1.0	1 (2%)	-	1.0
Hypoxia	13 (21%)	15 (31%)	0.27	6 (l0%)	11 (23%)	0.065
Pulmonary edema	4 (6%)	4 (8%)	0.73	1 (2%)	4 (8%)	0.16
Pleural effusion	1 (2%)	3 (6%)	0.31	-	1 (2%)	0.43
Epistaxis	7 (11%)	8 (17%)	0.42	-	1 (2%)	0.43
Respiratory Failure	3 (5%)	7 (15%)	0.097	3 (5%)	7 (l5%)	0.097

Note: Data are n (%).MI: myocardial infarction; ICH: intracranial hemorrhage; AMS: altered mental status; CNS: central nervous system.

^aData were analyzed using two-sided Fisher’s exact tests.