Table 5.
The association of H19 polymorphism and OSCC susceptibility.
| Inheritance model | Genotype | Cases n (%) n = 200 |
Controls n (%) n = 200 |
OR (95% CI) | P value | |
|---|---|---|---|---|---|---|
| rs217727 | Codominanta | CC | 110 (55) | 133 (66.5) | ||
| CT | 75 (37.5) | 64 (32) | 1.47 (0.93-2.15) | 0.10 | ||
| TT | 15 (7.5) | 3 (1.5) | 6.04 (1.70-21.42) | 0.001 | ||
| Dominantb | CC | 110 (55) | 133 (66.5) | |||
| CT+TT | 90 (45) | 67 (33.5) | 1.62 (1.08-2.43) | 0.01 | ||
| Recessivec | CC+CT | 185 (92.5) | 197 (98.5) | |||
| TT | 15 (7.5) | 3 (1.5) | 5.32 (1.51-18.69) | 0.003 | ||
| Overdominantd | CC+TT | 125 (62.5) | 136 (68) | |||
| CT | 75 (37.5) | 64 (32) | 1.27 (0.84-1.92) | 0.24 | ||
|
| ||||||
| rs2107425 | Codominant | CC | 79 (39.5) | 74 (37) | ||
| CT | 94 (47) | 101 (50.5) | 0.87 (0.57-1.33) | 0.52 | ||
| TT | 27 (13.5) | 25 (12.5) | 1.01 (0.53-1.89) | 0.97 | ||
| Dominant | CC | 79 (39.5) | 74 (37) | |||
| CT+TT | 121 (60.5) | 126 (63) | 0.89 (0.60-1.34) | 0.60 | ||
| Recessive | CC+CT | 173 (86.5) | 175 (87.5) | |||
| TT | 27 (13.5) | 25 (12.5) | 1.09 (0.60-1.95) | 0.76 | ||
| Overdominant | CC+TT | 106 (53) | 99 (49.5) | |||
| CT | 94 (47) | 101 (50.5) | 0.86 (0.58-1.28) | 0.48 | ||
OR, odd ratio; CI, confidence interval. aCodominant, major allele homozygotes vs. heterozygotes. bDominant, major allele homozygotes vs. heterozygotes + minor allele homozygotes. cRecessive, major allele homozygotes + heterozygotes vs. minor allele homozygotes. dOverdominant, major allele homozygotes + minor allele homozygotes vs. heterozygotes.