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. 2019 Oct 11;71(3):1037–1054. doi: 10.1002/hep.30882

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© The Authors. Hepatology published by Wiley Periodicals, Inc., on behalf of American Association for the Study of Liver Diseases.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Steap3 promotes apoptosis during hepatic I/R injury. (A) TUNEL staining in liver sections from WT and Steap3‐KO mice at 6 hours after hepatic I/R operation (n = 4/group). Scale bar, 50 μm. (B) mRNA levels of apoptosis‐related genes (Bad, Bax, and Bcl2) in liver samples of WT and Steap3‐KO mice at 6 hours after hepatic I/R operation (n = 6/group). (C) Western blot analysis of the Bax and Bcl2 levels in the liver of WT and Steap3‐KO mice at 6 hours after hepatic I/R operation. GAPDH served as a loading control (n = 3/group). (D) TUNEL staining in liver sections of NTG and Steap3‐HTG mice at 6 hours after hepatic I/R operation (n = 4/group). Scale bar, 50 μm. (E) mRNA levels of apoptosis‐related genes (Bad, Bax, and Bcl2) in liver samples from NTG and Steap3‐HTG mice at 6 hours after hepatic I/R operation (n = 6/group). (F) Western blot analysis of the Bax and Bcl2 levels in the liver of NTG and Steap3‐HTG mice at 6 hours after hepatic I/R operation. GAPDH served as a loading control (n = 3/group). All data are shown as the mean ± SD. Levels of statistical significance are indicated as *P < 0.05, **P < 0.01. For statistical analysis, one‐way ANOVA with Bonferroni’s post hoc analysis or Tamhane’s T2 post hoc analysis and two‐tailed Student t test were used. Abbreviations: HPF, high‐power field; n.s., not statistically significant.