Table 1.
Baseline characteristics of mantle cell lymphoma patients (n = 89) with frontline R‐CHOP.
| Characteristics at diagnosis | Number of patients (%) |
|---|---|
| Gender | |
| Male | 72 (81) |
| Female | 17 (19) |
| Age, median, years (range) | 64 (26–84) |
| ≥65 | 41 (46) |
| Pathological subtype | |
| Classic | 87 (98) |
| Small cell variant | 2 (2) |
| Ann‐Arbor stage | |
| II* | 8 (9) |
| III | 18 (20) |
| IV | 63 (71) |
| ECOG performance status | |
| 0 | 33 (37) |
| 1 | 44 (50) |
| 2 | 8 (9) |
| 3 | 4 (4) |
| Presence of B symptoms | 33 (37) |
| LDH, median (range) | 395 (158–5196) |
| Elevated (>450 U/l) | 34 (38) |
| WBC (×109/l), median (range) | 6·9 (1·9–60·3) |
| Ki‐67 index | |
| <30% | 56 (63) |
| ≥30% | 33 (37) |
| Presence of BM involvement | 55 (61) |
| Upfront auto‐HSCT | 19 (21) |
| IPI | |
| Low | 20 (22) |
| Low‐intermediate | 27 (30) |
| High‐intermediate | 22 (25) |
| High | 20 (22) |
| Standard MIPI | |
| Low | 37 (42) |
| Intermediate | 23 (26) |
| High | 29 (32) |
| Simplified MIPI | |
| Low | 38 (43) |
| Intermediate | 31 (35) |
| High | 20 (22) |
| Biological MIPI | |
| Low | 20 (22) |
| Intermediate | 21 (24) |
| High | 48 (54) |
| Combined MIPI | |
| Low | 23 (26) |
| Low‐intermediate | 31 (35) |
| High‐intermediate | 21 (23) |
| High | 14 (16) |
ECOG, Eastern Cooperative Oncology Group; LDH, lactate dehydrogenase; WBC, white blood cells; BM, bone marrow; HSCT, haematopoietic stem transplantation; IPI, International Prognostic Index; MIPI, Mantle Cell Lymphoma International Prognostic Index.
*
All cases with Ann‐Arbor stage II had a huge mass (≥10 cm).