Table 3.
Performance of the original and modified ACR/EULAR criteria sets with salivary gland ultrasonography (SGUS) replacing current itemsa
| AUC | 95% CI | Agreement | Sensitivity | Specificity | |
|---|---|---|---|---|---|
| Patients with labial gland biopsy (n = 124) | |||||
| Original ACR/EULAR criteria | 0.965 | 0.932–0.997 | 94.4 | 95.9 | 92.2 |
| SGUS replacing labial gland biopsy | 0.903 | 0.849–0.957 | 87.9 | 82.2 | 94.1 |
| SGUS replacing anti‐SSA antibodies | 0.943 | 0.902–0.985 | 89.5 | 86.3 | 94.1 |
| SGUS replacing OSS | 0.964 | 0.931–0.996 | 93.5 | 95.9 | 88.2 |
| SGUS replacing Schirmer's test | 0.969 | 0.938–1.000 | 93.5 | 94.5 | 92.2 |
| SGUS replacing UWS | 0.967 | 0.937–0.998 | 93.5 | 97.3 | 88.2 |
| Patients with parotid gland biopsy (n = 198) | |||||
| Original ACR/EULAR criteria | 0.954 | 0.925–0.984 | 92.9 | 91.4 | 95.1 |
| SGUS replacing parotid gland biopsy | 0.925 | 0.887–0.962 | 88.4 | 83.8 | 95.1 |
| SGUS replacing anti‐SSA antibodies | 0.918 | 0.879–0.956 | 86.9 | 79.5 | 97.5 |
| SGUS replacing OSS | 0.964 | 0.938–0.990 | 93.4 | 92.3 | 95.1 |
| SGUS replacing Schirmer's test | 0.964 | 0.939–0.989 | 89.9 | 84.6 | 97.5 |
| SGUS replacing UWS | 0.969 | 0.946–0.992 | 92.9 | 90.6 | 96.3 |
a
Values are the percentage unless indicated otherwise. In all criteria sets, a weight of 1 point for SGUS and cutoff value of ≥4 for fulfilment of the criteria was used. ACR = American College of Rheumatology; EULAR = European League Against Rheumatism; AUC = area under the curve; 95% CI = 95% confidence interval; OSS = ocular staining score; UWS = unstimulated whole saliva flow.